methylprednisolone sodium succinate

P2, N=60, Recruiting, Mayo Clinic | Trial completion date: Jul 2026 --> Jul 2027 | Trial primary completion date: Feb 2026 --> Feb 2027

P1/2, N=55, Suspended, Masonic Cancer Center, University of Minnesota | Recruiting --> Suspended

P1, N=35, Not yet recruiting, Baylor College of Medicine | Initiation date: Jan 2026 --> Jun 2026

We report a fulminant case of overlap syndrome involving ICI-induced myositis and myasthenia gravis in a 72-year-old man receiving ipilimumab-nivolumab for hepatocellular carcinoma and recurrent renal cell carcinoma...Despite prompt intensive care admission and treatment with high-dose intravenous methylprednisolone and intravenous immunoglobulin, only partial clinical improvement was achieved. The subsequent development of aspiration pneumonia led to acute respiratory and hepatic failure, culminating in death. This case underscores the aggressive clinical trajectory and high mortality of ICI-related neuromuscular overlap syndromes, highlighting the critical need for early recognition, rapid immunosuppression, and multidisciplinary management.

P3, N=110, Recruiting, Fondation Hôpital Saint-Joseph | Trial primary completion date: Oct 2025 --> Mar 2026

P2, N=163, Recruiting, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Trial completion date: May 2027 --> Feb 2027 | Trial primary completion date: Apr 2027 --> Aug 2026

P1/2, N=6, Active, not recruiting, Prevail Therapeutics Inc. | Suspended --> Active, not recruiting

P1/2, N=15, Recruiting, Cedars-Sinai Medical Center | Trial completion date: Sep 2026 --> Sep 2027 | Trial primary completion date: Sep 2026 --> Sep 2027

P4, N=198, Recruiting, Tianjin Medical University General Hospital

P2/3, N=212, Recruiting, Sint Maartenskliniek Stichting

Given the clinical presentation, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis was initially suspected, and the patient was treated with intravenous methylprednisolone and intravenous immunoglobulin, resulting in significant improvement...The clinical presentation and paraneoplastic association with teratoma closely resemble anti-NMDAR encephalitis, suggesting that anti-NCAM1 antibodies may define a novel form of AE with psychotic manifestations. Further research is needed to clarify their role in neuroinflammatory disorders.

P4, N=200, Not yet recruiting, Chinese PLA General Hospital