mitomycin

P1, N=42, Recruiting, Second Affiliated Hospital, School of Medicine, Zhejiang University

Tracheal epithelial cells were stimulated with GM-CSF and then treated after 24 h by lentivirus-mediated ADAM17 RNAi and mitomycin C. A model of severe traumatic tracheal stenosis was established in Beagle dogs...In conclusion, it was showed that TAPI-1 combined with silicone stents can significantly alleviate severe traumatic tracheal stenosis in Beagle dogs by inhibiting the ADAM17/TGF-β1 signaling pathway and expanding the narrowed trachea. TAPI-1 combined with silicone stents can be considered as a novel therapeutic approach for treating severe tracheal stenosis after trauma.

PMDOs can be completely eradicated if MMC treatment is followed by inhibition of ATR or other DDR kinases. DDR inhibitors may therefore have value in the adjuvant treatment of peritoneal metastases following CRS-HIPEC.

Additionally, the study explored the correlation between CALR and immune cell infiltration, as well as its interaction with mitomycin using molecular docking methods...Laboratory investigations have demonstrated that reducing CALR expression can lessen the stemness features of BLCA. Our results highlight the critical role of genes related to stem cells in BLCA and identify CALR as a promising target associated with stem cell functionality.

P2/3, N=33, Active, not recruiting, University of Cincinnati | Recruiting --> Active, not recruiting

P2, N=40, Recruiting, Mayo Clinic | Trial completion date: May 2027 --> Jul 2029 | Trial primary completion date: May 2026 --> Jul 2029

CRS and HIPEC provide 14% 5-year survival for GCA with peritoneal metastases. Complete cytoreduction, especially with PCI < 20, improves outcomes.

This case highlights the potential role of chemoradiotherapy in managing pelvic squamous cell CUP, achieving durable remission in selected patients.

SQAP sensitized series of chemotherapeutic agents including doxorubicin, carboplatin, bleomycin, camptothecin, etoposide, methyl methanesulfonate, cisplatin, mitomycin C, and Taxol in canine tumor cells and V79 cells. These results suggest that broad inhibition of DNA repair may play a role in SQAP induced radiosensitization and chemosensitization.

This case report supports the clinical utility of pre-emptive DPYD genotyping to guide initial 5-FU dosing in intermediate metabolizers, and it suggests that all patients still require close monitoring and some (particularly carriers of c.2846 A > T) may require an initial dose reduction greater than the recommended 50% to prevent severe toxicity.

Mitomycin-C had limited activity in HPV-positive, and no activity in HPV-negative, platinum-refractory RM-HNSCC.

P3, N=220, Recruiting, Janssen Research & Development, LLC | Trial primary completion date: Aug 2027 --> Apr 2028