Ocular Melanoma

Furthermore, the anti-tumor effect of CM-Thy was validated through various mechanisms involved in tumor formation such as angiogenesis and vasculogenic mimicry. Interestingly, the results from visible light experiments conducted in vitro also substantiated the remarkable therapeutic efficacy of this system for refractive eye disorders while providing innovative ideas for cross-species biological interventions.

Although agents such as lenalidomide and Bruton's tyrosine kinase(BTK) inhibitors have demonstrated efficacy in relapsed/refractory (R/R)PVRL, their role in treatment-naïve patients remains unclear. In conclusion, the combination of Orelabrutinib, rituximab, and intravitreal MTX is a feasible therapeutic strategy for PVRL. Our findings may contribute to a potential paradigm shift in the management of this rare disease.

Additionally, we discuss its interactions with autophagy, cellular senescence, and cell death, exploring its potential as a therapeutic target in inflammatory and neoplastic eye conditions. Finally, we identify key unresolved questions and outline future research directions aimed at exploiting cGAS-STING modulation for precision therapies in vision-threatening diseases.

P1, N=36, Not yet recruiting, Aura Biosciences, Inc.

P=N/A, N=500, Active, not recruiting, Leiden University Medical Center | Recruiting --> Active, not recruiting | Trial completion date: Sep 2030 --> Apr 2031 | Trial primary completion date: Sep 2025 --> Apr 2028

SARDS and CAR share immune-related molecular signatures but potentially differ in secondary mechanisms-vascular inflammation and endothelial activation in SARDS versus paraneoplastic mimicry in CAR. These data provide potential insight into the pathogenesis of SARDS as well as CAR, and identify potential diagnostic and therapeutic targets.

No systemic toxicity was observed in hematological, biochemical, or histological analyses. We demonstrate that macrophage-targeted MPLA-LNP delivery of TYRP1-CAR mRNA in a murine choroidal melanoma model reprograms tumor-associated macrophages toward an M1 phenotype, suppresses tumor growth, and prolongs survival through combined antigen-specific targeting and microenvironment remodeling.

Although extremely rare, intraocular ependymoma should be included as part of the differential diagnosis of retinal and ciliary body tumors in childhood.

P1, N=17, Completed, H. Lee Moffitt Cancer Center and Research Institute | Active, not recruiting --> Completed

Both the BM-MSCs and tumor cells exhibited altered secretory profiles after sEV treatment. The in vitro findings provide cumulative evidence that sEV-mediated interactions contribute to a tumor-supportive milieu or premetastatic niche at the BM in Rb.

Genetic testing identified a KMT2D gene mutation, confirming a diagnosis of Kabuki syndrome. Her left eye is developing normally with no structural abnormalities.

P=N/A, N=100, Recruiting, University of Washington | Active, not recruiting --> Recruiting