Oral Cancer

This study highlights salivary MMP-9 and MMP-2, together with MMP activity, as biomarkers of interest for OSCC that may contribute to the understanding of disease-related molecular changes detectable by liquid biopsy. While elevated salivary levels were observed in OSCC cases when compared to controls, these findings should be interpreted as exploratory. Elevated serological MMP-9 levels were observed in a small subset of cases. However, the limited sample size and the absence of a control group in this study preclude diagnostic interpretation. Larger, well-powered, and externally validated studies are required to determine the potential clinical utility of these biomarkers.

IL-27 promotes OSCC progression by upregulating FSIP1, leading to PI3K-Akt pathway activation, enhanced proliferation and migration, and reduced apoptosis. FSIP1 represents a central mediator of the oncogenic activity of IL-27 and may serve as a potential therapeutic target in OSCC.

Instead, overcoming ICB resistance in OSCC requires a precision strategy focused on targeting cell-specific CXCL9 signaling. Ultimately, dissecting and therapeutically navigating the source-specific CXCL9 network is essential to transform the OSCC TME and improve clinical outcomes.

HER1 and Ki-67 emerged as strong predictors of tumour aggressiveness, while HER3 and HER4 were linked with advanced disease characteristics. Therapy against these markers could be promising in OSCC.

Its overexpression correlates with poor prognosis and represents a potential diagnostic and therapeutic target. Furthermore, targeting TNFRSF10B may restore apoptosis, thus making precision therapy achievable.

nucleatum colonization correlates with increased c-Myc expression in OPMDs and OSCC, supporting its possible role in microbially driven oral carcinogenesis. These findings suggest its potential as a prognostic biomarker and a therapeutic target.

To overcome these obstacles, we developed a composite biomimetic nanodelivery system comprising two distinct formulations: platelet membrane-coated liposomes encapsulating berberine (BBR) and ginsenoside Rg3 (RG3) (B@R/PL) for stromal modulation, and liposomes modified with a neutrophil extracellular trap (NET)-derived DNA-protein network co-loading paclitaxel (PTX) and a photothermal agent (PCP) (P&P/NL) for synergistic killing...Furthermore, the treatment reshaped the immune microenvironment, evidenced by markedly elevated levels of tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), and interleukin-6 (IL-6), alongside decreased interleukin-10 (IL-10) in tumor tissues. Collectively, this TME-programming biomimetic strategy provides a promising approach with clinical translation potential to overcome TME barriers and achieve efficient anti-tumor and anti-metastasis therapy.

This study suggests potential associations: HLA-DRB1*10, DPB1*02, DPB1*04, DPB1*05, DRB1*16-DPB1*02, and DRB1*16-DPB1*05 could potentially exert a protective effect against OSF-derived OSCC. In contrast, DRB1*14-DPB1*02 significantly increases the risk of OSCC, whereas DRB1*11-DQB1*06 and DRB1*14-DPB1*02 may promote progression from OSF to OSCC. Additionally, DRB1*10 is a potential susceptibility gene for OSF but may also inhibit progression from OSF to OSCC.

P3, N=290, Active, not recruiting, ECOG-ACRIN Cancer Research Group | Recruiting --> Active, not recruiting

Serum TSA and CEA are promising biomarkers for the early diagnosis and differentiation of OSCC and OSMF. TSA also helps distinguish periodontitis associated with OSCC from periodontitis without OSCC. Their significant association with clinical stage and histopathological grade underscores their potential role in disease progression assessment. Future studies should explore these findings in larger populations and combining the present data point of care diagnostics can be conceptualized.

These findings underscore the need for targeted interventions, such as epigenetic therapies, metabolic reprogramming, and robust tobacco control policies, to mitigate the global burden of tobacco-related diseases. By providing a unified framework for understanding tobacco's molecular impact, this research advocates for precision medicine and public health strategies to address the pervasive effects of tobacco on human health.