^
    1d
    Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) (clinicaltrials.gov)
    P2, N=20, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Mar 2026 --> Mar 2027
    Trial completion date
    |
    ulixertinib (BVD-523)
    1d
    Evaluating Efficacy of B7-H3-CAR T Cells Administered at the End of Upfront Map Chemotherapy in Patients With Newly Diagnosed High-Risk Osteosarcoma (clinicaltrials.gov)
    P2, N=41, Not yet recruiting, St. Jude Children's Research Hospital | Initiation date: Feb 2026 --> Jun 2026
    Trial initiation date
    |
    cyclophosphamide • fludarabine IV • mesna • B7-H3 CAR-T
    1d
    MiR-21 targets PDCD4 to regulate proliferation, apoptosis, and invasion of osteosarcoma MG63 cells (PubMed, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi)
    In contrast, down-regulation of miR-21 expression inhibits proliferation and invasion while promoting apoptosis of osteosarcoma cell line MG63. Therefore, miR-21 functions as an oncogene in the development of osteosarcoma and could be a potential therapeutic target.
    Journal
    |
    MIR21 (MicroRNA 21)
    2d
    Research and Application Promotion of Key Technologies in Minimally Invasive and Precise Resection and Reconstruction for Periaritcular Bone Tumors of the Knee (ChiCTR2600117848)
    P=N/A, N=12, Completed, West China Hospital, Sichuan University; West China Hospital, Sichuan University
    New trial
    3d
    Integrated Multiomic Profiling Enhances Risk Stratification and Prognostication in Canine Osteosarcoma. (PubMed, Clin Cancer Res)
    This work highlight the complexity of the disease and provide new insight into the utility of prognostic biomarkers and potential druggable targets for future study.
    Journal
    |
    TP53 (Tumor protein P53) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog)
    |
    TP53 mutation • PTEN mutation
    3d
    Giant Cell Tumor of the Cranial Vault: A Rare Frontotemporal Case With Complete Neurological Recovery and Narrative Review. (PubMed, Cureus)
    This case is discussed within the context of a comprehensive narrative review highlighting the distinct biological behavior of calvarial GCTB compared to skull-base lesions, the critical importance of achieving gross total resection, and the emerging role of molecular diagnosis (H3F3A G34W mutation) and adjuvant therapies including denosumab. Calvarial GCTB offers superior surgical accessibility and prognosis compared to skull-base counterparts, with appropriately aggressive resection typically achieving cure without need for radiotherapy, thereby avoiding the well-documented risk of radiation-induced malignant transformation.
    Journal
    |
    CD68 (CD68 Molecule) • H3-3A (H3.3 Histone A)
    |
    Prolia (denosumab)
    3d
    Rib-Origin Ewing Sarcoma With Cranial Nerve Involvement From Orbital Metastasis: A Rare Case Report. (PubMed, Clin Case Rep)
    Timely intervention is important in Ewing sarcoma owing to the risk of metastasis. Radiation, chemotherapy, and surgical interventions can be used depending upon the patient's prognosis.
    Journal
    |
    EWSR1 (EWS RNA Binding Protein 1) • FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • CD99 (CD99 Molecule)
    3d
    One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH-SY5Y and U-87 MG cancer cells. (PubMed, FEBS Open Bio)
    Lastly, we show that a clinically achievable BaP concentration enhanced the antiproliferative effects of temozolomide on glioblastoma cells. These findings show that drugs that have been successfully repurposed to potentially treat some types of cancers may have use in other cancers, but that their efficacy and mechanisms of action do not necessarily translate from one cancer type to another. Thus, successful drug repurposing requires investigation and optimisation on a case-by-case basis.
    Preclinical • Journal
    |
    SCD (Stearoyl-CoA Desaturase)
    |
    temozolomide
    3d
    Fosb promotes ferroptosis in vascular smooth muscle cells via the NF-κB pathway to exacerbate abdominal aortic aneurysm progression. (PubMed, Cell Signal)
    Fosb drives SMC ferroptosis and inflammatory phenotypic switching, via NF-κB pathway activation, thereby reinforcing AAA progression. Targeting Fosb or the ferroptosis pathway may provide new therapeutic strategies for AAA treatment.
    Journal
    |
    APOE (Apolipoprotein E)
    |
    KIT expression
    3d
    ISOMUTAR: Functional Outcomes of Knee Protheses for Malignant Tumours of Bone (clinicaltrials.gov)
    P=N/A, N=9, Completed, University Hospital, Lille | Terminated --> Completed
    Trial completion
    4d
    Aerosolized Aldesleukin in Treating Patients With Lung Metastases (clinicaltrials.gov)
    P1, N=70, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: Apr 2026 --> Apr 2029 | Trial primary completion date: Apr 2026 --> Apr 2029
    Trial completion date • Trial primary completion date
    |
    Proleukin (aldesleukin)