Osteosarcoma

RNA sequencing analysis demonstrated that NP3 synergistically promoted tumor regression by concurrently inducing pro-apoptotic signaling and immune responses. In conclusion, this study presents an innovative therapeutic strategy combining targeted chemotherapy delivery with robust antitumor metalloimmunotherapy, offering a promising therapeutic approach for OS.

This case highlights key perioperative considerations, outlines the main aspects of our anesthetic approach, and represents the first report of anesthesia for major orthopedic surgery in a patient with RTS. It emphasizes the importance for anesthesiologists to understand the multisystemic manifestations of this disorder, to engage in careful preoperative planning, as well as the need for disease-specific anesthetic guidelines to ensure safe and optimized perioperative care.

This study demonstrated that GPX8 is a critical oncogene in OS progression and that its expression is regulated by KLF16. Targeting the KLF16/GPX8 axis may offer promising prospects for the development of novel therapeutic strategies against OS.

P=N/A, N=362, Completed, University of Minnesota | Recruiting --> Completed | N=5000 --> 362

P1/2, N=90, Recruiting, St. Jude Children's Research Hospital | Active, not recruiting --> Recruiting | N=46 --> 90

This case highlights the diagnostic complexities of round cell sarcoma of bone, which can mimic other benign bone lesions. It underscores the importance of multidisciplinary evaluation, genetic testing, and timely oncological intervention to improve patient outcomes.

These results suggest that, compared to parental MG-63 cells, highly migratory osteosarcoma MG63-R10 cells adapt their malignant cellular functions to hypoxic and low-glucose conditions through LPA receptor signaling, highlighting this pathway as a potential therapeutic target in aggressive osteosarcomas. The online version contains supplementary material available at 10.1007/s12195-025-00873-y.

In the presence of caspase-3, the fluorescence of TAMRA can be recovered by cleavage of 5-TAMRA-pep, while the upconversion luminescence (UCL) intensity of UCNP is kept as constant. The UCNP@PDA@5-TAMRA-pep has been successfully used to accurately evaluate cisplatin's (cis-Pt's) concentration-dependent apoptotic effect on mouse-bearing MG-63 tumor model through in site monitoring caspase-3 activity.

SBRT emerges as an attractive combination strategy to augment the efficacy of ICI-based immunotherapy in R/R osteosarcoma.

Emerging approaches, including metabolic reprogramming, noncoding RNA regulation, and precision biomarkers such as miRNAs and histone modifications, offer promising tools for diagnosis, risk stratification, and treatment optimization. By linking the molecular mechanisms of p53 with novel therapeutic strategies, this review underscores opportunities for translational research aimed at improving the clinical outcomes of OS patients.

Overexpression of VEGF, HIF-1α, Ezrin, and p53 was strongly associated with increased mortality risk in osteosarcoma. These findings may guide patient counselling, biomarker panel optimization, and the development of targeted therapies.

Mechanistically, the effects driven by MIR17HG were abolished by miR-372-3p overexpression, and BCL6 was identified as a direct functional target of miR-372-3p. These findings demonstrate that exosomal MIR17HG derived from hMSCs drives the differentiation of follicular helper T cells and the progression of OS via the miR-372-3p/BCL6 axis.