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    CANCER:

    Ovarian Serous Adenocarcinoma

    Related cancers:
    3d
    Avutometinib and defactinib: a novel dual pathway inhibition strategy for recurrent KRAS-mutant low-grade serous ovarian cancer. (PubMed, Int J Gynecol Cancer)
    The authors discuss adverse event management and the implications for integration into routine clinical practice. Clinicians caring for patients with low-grade serous ovarian carcinoma can use the drug knowledge and evidence outlined in this review to assist with implementing avutometinib and defactinib therapy.
    Review • Journal
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    KRAS (KRAS proto-oncogene GTPase)
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    KRAS mutation
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    Avmapki (avutometinib) • Fakzynja (defactinib)
    3d
    Spatial integration of protein and chromosomal states reveals early copy number changes and genotype-associated immune neighborhoods in serous ovarian cancer evolution. (PubMed, Cancer Discov)
    In addition, epithelial cells with MYC and CCNE1 copy-number gains were detected in morphologically normal fallopian tube epithelium, along with rare MDM4 increases across epithelial lineages. Together, ORION-FISH provides a framework linking chromosomal copy number states to protein-defined phenotypes within preserved tissue architecture, enabling context-aware interrogation of early copy-number diversification at single-cell resolution.
    Journal
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    CCNE1 (Cyclin E1) • MDM4 (The mouse double minute 4)
    13d
    Epigenetic Compound Library Screen Identifies Ibrutinib as an Inhibitor of Ovarian Clear Cell Carcinoma Viability. (PubMed, Cancer Med)
    Ibrutinib is used clinically to treat specific B cell disorders; however, it is not currently approved to treat solid tumours. Data presented in OCCC cell lines complements clinical observations of a therapeutic response to ibrutinib in low-grade serous ovarian cancer. Ibrutinib demonstrates potential for the treatment of certain rare subtypes of ovarian cancer and should be further investigated.
    Journal • IO biomarker
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    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • ARID1A (AT-rich interaction domain 1A)
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    PIK3CA mutation • ARID1A mutation
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    Imbruvica (ibrutinib)
    14d
    Letrozole for Estrogen/Progesterone Receptor Positive Low-grade Serous Epithelial Ovarian Cancer (LEPRE Trial) (clinicaltrials.gov)
    P3, N=142, Recruiting, Ente Ospedaliero Ospedali Galliera
    New P3 trial
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    AR (Androgen receptor)
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    carboplatin • paclitaxel • letrozole
    15d
    Testing the Combination of APG-1252 (Pelcitoclax) and Cobimetinib in Recurrent Ovarian and Endometrial Cancers (clinicaltrials.gov)
    P1, N=42, Active, not recruiting, National Cancer Institute (NCI) | Recruiting --> Active, not recruiting
    Enrollment closed
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    BRAF (B-raf proto-oncogene)
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    Cotellic (cobimetinib) • pelcitoclax (APG-1252)
    17d
    In Silico Multi-omics Analyses of Kinesin Family Member 15 in Pan-Cancer and Validation in Tissue Microarray. (PubMed, Curr Cancer Drug Targets)
    KIF15 may serve as a potential biomarker and oncogenic factor in multiple cancer types.
    Journal • Pan tumor
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    KIF15 (Kinesin Family Member 15)
    19d
    Study of High Levels of Wilms' Tumor 1 (WT1) Expression in Ovarian Cancers. (PubMed, Cureus)
    The association between WT1 positivity and advanced tumor stage suggests a potential prognostic role. Incorporation of WT1 immunohistochemistry into routine diagnostic practice may enhance tumor classification and provide insights into disease progression in ovarian cancer.
    Journal
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    WT1 (WT1 Transcription Factor)
    21d
    FLORA-4: Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery (clinicaltrials.gov)
    P3, N=615, Active, not recruiting, CanariaBio Inc. | Trial primary completion date: Mar 2026 --> Dec 2026
    Trial primary completion date
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    carboplatin • paclitaxel • OvaRex (oregovomab)
    21d
    QPT-ORE-006: Oregovomab Plus Chemotherapy in Neo-adjuvant Setting in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer (clinicaltrials.gov)
    P2, N=88, Active, not recruiting, CanariaBio Inc. | Trial primary completion date: Jan 2026 --> Oct 2026
    Trial primary completion date
    |
    carboplatin • paclitaxel • OvaRex (oregovomab)
    28d
    Letrozole for Estrogen/Progesterone Receptor Positive Low-grade Serous Epithelial Ovarian Cancer (LEPRE Trial) (clinicaltrials.gov)
    P3, N=132, Recruiting, Ente Ospedaliero Ospedali Galliera | Not yet recruiting --> Recruiting
    Enrollment open
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    AR (Androgen receptor)
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    carboplatin • paclitaxel • letrozole
    30d
    APL-2 and Pembrolizumab Versus APL-2, Pembrolizumab and Bevacizumab Versus Bevacizumab Alone for the Treatment of Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer and Malignant Effusion (clinicaltrials.gov)
    P2, N=60, Recruiting, Roswell Park Cancer Institute | Trial completion date: Apr 2027 --> Apr 2028 | Trial primary completion date: Apr 2026 --> Apr 2028
    Trial completion date • Trial primary completion date
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    Keytruda (pembrolizumab) • Avastin (bevacizumab) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn)