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    BIOMARKER:

    PAICS expression

    i
    Other names: PAICS, Phosphoribosylaminoimidazole Carboxylase And Phosphoribosylaminoimidazolesuccinocarboxamide Synthase, AIRC, Phosphoribosylaminoimidazole Carboxylase, Phosphoribosylaminoimidazole Succinocarboxamide Synthetase, Multifunctional Protein ADE2, ADE2H1, ADE2, PAIS, Phosphoribosylaminoimidazole Carboxylase; Phosphoribosylaminoimidazolesuccinocarboxamide Synthase, Multifunctional Protein ADE2H1, SAICAR Synthetase, AIR Carboxylase
    Entrez ID:
    10606
    Related biomarkers:
    Expression
    Associations

    News

    Trials
    1year
    Role of CENPL, DARS2, and PAICS in determining the prognosis of patients with lung adenocarcinoma. (PubMed, Transl Lung Cancer Res)
    The CENPL, DARS2, and PAICS expression was negatively correlated with LUAD prognosis. A prognostic model, which integrated DARS2, PAICS, and other clinicopathological variables, was able to effectively predict LUAD patients prognosis.
    Journal
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    PAICS (Phosphoribosylaminoimidazole Carboxylase And Phosphoribosylaminoimidazolesuccinocarboxamide Synthase)
    |
    PAICS expression
    over1year
    Genome-scale CRISPR-Cas9 screen identifies PAICS as a therapeutic target for EGFR wild-type non-small cell lung cancer. (PubMed, MedComm (2020))
    Moreover, decreased IMPDH2 activity and activated PI3K-AKT signaling were observed in NSCLC cells with EGFR mutations, which may compromise the effectiveness of PAICS knockdown. Therefore, PAICS plays an oncogenic role in EGFR wild-type NSCLC and represents a potential therapeutic target for this disease.
    Journal
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    EGFR (Epidermal growth factor receptor) • PAICS (Phosphoribosylaminoimidazole Carboxylase And Phosphoribosylaminoimidazolesuccinocarboxamide Synthase)
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    EGFR mutation • EGFR wild-type • PAICS expression
    over4years
    PAICS is related to glioma grade and can promote glioma growth and migration. (PubMed, J Cell Mol Med)
    Our results indicated that PAICS can promote glioma proliferation and migration. PAICS may act as a potential diagnostic marker and a therapeutic target for glioma.
    Journal
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    ERCC1 (Excision repair cross-complementation group 1) • XPA (XPA, DNA Damage Recognition And Repair Factor) • PAICS (Phosphoribosylaminoimidazole Carboxylase And Phosphoribosylaminoimidazolesuccinocarboxamide Synthase)
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    PAICS expression
    almost5years
    Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer. (PubMed, PLoS One)
    In conclusion, our results suggest that PAICS expression is downregulated during tumor progression due to genetic deletion of chromosome 4q in microsatellite stable but chromosomally unstable tumors. Furthermore, decreased expression of PAICS transcript or loss of PAICS protein may provide prognostic stratification for postoperative patients with stage III CRC.
    Journal
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    PAICS (Phosphoribosylaminoimidazole Carboxylase And Phosphoribosylaminoimidazolesuccinocarboxamide Synthase)
    |
    PAICS expression