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    DRUG CLASS:

    PIGF inhibitor

    Related drugs:
    2d
    The Efficacy of Intravitreal Aflibercept Injection in Improvement of Retinal Nonperfusion in Diabetic Retinopathy (clinicaltrials.gov)
    P2, N=38, Completed, Asan Medical Center | Unknown status --> Completed
    Trial completion
    14d
    SAHLVE: The Sahlgrenska Anti-VEGF Study (clinicaltrials.gov)
    P2, N=402, Active, not recruiting, Vastra Gotaland Region | Recruiting --> Active, not recruiting | Trial completion date: Sep 2024 --> May 2027 | Trial primary completion date: Sep 2024 --> Oct 2026
    Enrollment closed • Trial completion date • Trial primary completion date
    |
    Avastin (bevacizumab)
    15d
    Real-Life Clinical Outcomes of Aflibercept Biosimilar MY-1701P in the Treatment of Exudative Age-Related Macular Degeneration (clinicaltrials.gov)
    P=N/A, N=54, Not yet recruiting, Saglik Bilimleri Universitesi
    New trial • Real-world evidence
    17d
    The SPECTRUM Study: An Observational Study to Learn More About How Well Aflibercept 8 mg Works in Treating Visual Impairment Due to Neovascular Age-related Macular Degeneration or Diabetic Macula Edema (clinicaltrials.gov)
    P=N/A, N=2500, Active, not recruiting, Bayer | Recruiting --> Active, not recruiting
    Enrollment closed • Real-world evidence
    22d
    ZEB1 and Uveal Melanoma Invasiveness. (PubMed, Int J Mol Sci)
    Effects of siRNA-dependent ZEB1 knockdown on UM cell proliferation and their sensitivity to the VEGF-A inhibitor Eylea (aflibercept) were tested by MTT and in a real-time proliferation assay...In addition, there is probably a ZEB1 feedback loop that is sensitive to a drop in VEGF-A concentration. The data obtained allow us to consider ZEB1 silencing as an auxiliary link for a combined strategy of killing UM cells.
    Journal
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    KDR (Kinase insert domain receptor) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)
    1m
    DEUTERON: A Study to Learn About the Blood Levels of Aflibercept When High-dose Aflibercept is Injected in Both Eyes of Participants With Diabetic Macular Edema or Neovascular Age-related Macular Degeneration (clinicaltrials.gov)
    P4, N=51, Completed, Bayer | Active, not recruiting --> Completed
    Trial completion
    1m
    A Comparative Study on the Efficacy of Aflibercept biosimilar versus the Aflibercept Intravitreous Injection in the Treatment of Refractory nAMD (ChiCTR2500108770)
    P=N/A, N=80, Not yet recruiting, Shandong Provincial Hospital Affiliated to Shandong First Medical University; Shandong Provincial Hospital Affiliated to Shandong First Medical Univer
    New trial
    1m
    VGFTe-OD-2457: A Real-World Evidence Study for the Incidence of Retinal Vasculitis (RV) Among Adult Patients Receiving Aflibercept 2 mg in the United States (US) (clinicaltrials.gov)
    P=N/A, N=550000, Completed, Regeneron Pharmaceuticals | Recruiting --> Completed
    Trial completion • HEOR • Real-world evidence
    1m
    Leveraging the htsFLT01/MiRGD Complex to Enhance Apoptosis and Suppress Angiogenesis in MCF7 Breast Cancer Cells. (PubMed, Iran J Med Sci)
    This study evaluated the effect of this complex on apoptosis induction in MCF7 cells via the extrinsic apoptotic pathway, revealing increased expression of FADD, CASP8, and p53 genes. These findings highlight a synergistic relationship between anti-angiogenic and pro-apoptotic mechanisms, offering promising avenues for future breast cancer therapies.
    Journal
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    FADD (Fas associated via death domain) • CASP8 (Caspase 8)
    |
    GZ402663
    2ms
    FIREFLEYE next: Extension Study to Evaluate the Long-term Outcomes of Subjects in Study 20090 (clinicaltrials.gov)
    P3, N=100, Completed, Bayer | Active, not recruiting --> Completed
    Trial completion
    2ms
    Incidence of Retinal Vasculitis Among Patients Receiving Aflibercept: A US Real-World Evidence Study (clinicaltrials.gov)
    P=N/A, N=290000, Completed, Regeneron Pharmaceuticals | Recruiting --> Completed
    Trial completion • HEOR • Real-world evidence
    2ms
    Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma (clinicaltrials.gov)
    P2, N=3, Terminated, Sidney Kimmel Cancer Center at Thomas Jefferson University | Completed --> Terminated; Slow accrual
    Trial termination
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    Zaltrap (ziv-aflibercept IV)