PIK3CA mutation

HER2-high and HER2-low/TNBC breast cancers demonstrate distinct clinicopathologic and molecular profiles. Therapy-associated enrichment of PIK3CA mutations and their association with aggressive behavior underscore their prognostic and therapeutic significance in HER2-positive disease. Further studies are needed to clarify their role in guiding personalized treatment strategies.

In the CAPItello-291 trial, capivasertib and fulvestrant demonstrated efficacy in patients with up to two prior lines endocrine therapy, but its use in late-line settings has not yet been reported. In this article, we report a case of a woman with metastatic recurrent breast cancer who was treated with capivasertib and fulvestrant was used as the late-line treatment, resulting in a progression-free survival of 8 months.

P=N/A, N=500, Not yet recruiting, Hoffmann-La Roche

This is the first real world evidence of the potential prognostic significance of VAF in mCRC. Patients with low RAS VAF had better survival compared with high VAF counterparts. Presence of low RAS VAF in tumour samples may suggest that patients progress in a manner resembling RAS wild-type tumours.

In summary, we identified a distinct oncogenic pathway in CCA of the urinary bladder, most commonly involving activation of the PI3K/AKT/mTOR pathway through gain-of-function mutations in PIK3CA (74%) and/or KRAS (26%). These tumours frequently harbour loss-of-function mutations in tumour suppressor genes (TP53, SMAD4, RB1 and APC) and point/missense mutations of proto-oncogenes (ERBB2 and MET). Our study also highlights potential therapeutic targets for this aggressive malignancy.

The data are in line with current literature that targeted treatment is being applied for selected LC patients in CZ. It can be expected that LC patients benefit from therapeutic and other clinical improvements, which however do not reduce the primary importance of anti-smoking campaigns.

P2, N=24, Active, not recruiting, Novartis Pharmaceuticals | Trial completion date: Jul 2026 --> Jan 2027 | Trial primary completion date: Jun 2026 --> Jan 2027

P2, N=124, Recruiting, Alliance for Clinical Trials in Oncology | Trial primary completion date: Jan 2026 --> Jan 2027

Our study delineates the distinct genomic mutational landscapes between TNBC and non-TNBC cohorts, and reveals somatic interactions, driver genes, mutational signatures and pathway enrichment. These findings highlight the distinct molecular features of TNBC, which may contribute to its aggressive clinical behavior.

This technology represents a significant advancement in molecular diagnostics by integrating mutation detection and clonality assessment in a single assay. Its cost-effective design and modular architecture make it adaptable for various oncogenic mutations, providing clinicians with a powerful tool for therapy selection and tumor heterogeneity monitoring. The platform's capabilities in detecting low-frequency variants suggest promising applications in minimal residual disease monitoring and liquid biopsy analysis, potentially transforming precision oncology practice. Future development will focus on enhancing multiplexing capacity and microfluidic integration to further expand its clinical utility.

To our knowledge, this is the first report of dual TERTp mutations detected in the preoperative setting in thyroid carcinoma. Clinical correlation with future cases will be of interest, particularly if cases with monoallelic dual TERTp mutations are discovered.

Our findings demonstrate potential driver genes and mutational hotspots associated with CRC patient, characterizing the mutational landscape related to clinical characteristics. Significantly advancing our understanding of CRC's heterogeneous nature, this study lays a solid foundation for devising more efficacious management strategies.