Pituitary Gland Carcinoma

Furthermore, novel SRL formulations and the identification of new molecular targets could further expand the therapeutic landscape of POMT. In this narrative review, we systematically summarize the latest research advancements in POMT for acromegaly and discusses potential therapeutic strategies and persisting obstacles in this field.

The p53 and Ki-67 also consistently exhibited increased or abnormal expression. Due to the overlapping histological and immunohistochemical features of odontogenic-type carcinomas and SCC, careful assessment is recommended when diagnosing recurrent CPs.

P=N/A, N=110, Recruiting, Mayo Clinic

This case highlights a tumor with features of both neuronal and endocrine neoplasms. Although their presentation resembles that of pitNETs, their treatment response and behavior are more consistent with glioneuronal tumors, resulting in a highly favorable phenotype and treatment response.

Histogram analysis of both CE-T1WI and the subtraction between CE-T1WI and T1WI could differentiate gonadotroph macroadenomas from non-gonadotroph macroadenomas. The CE-T1WI histogram parameters were correlated with the Ki-67 and P53 expression levels in the macroadenomas.

P=N/A, N=530, Active, not recruiting, University Hospital, Basel, Switzerland | Recruiting --> Active, not recruiting | N=200 --> 530

Transcription factor expression was associated with distinct clinical features and short-term outcomes. The PIT1 and TPIT lineages were linked to shorter tumor-free survival. Enhanced postoperative surveillance is recommended for these subgroups. These findings underscore the clinical and prognostic heterogeneity of non-functioning PitNETs.

Monitoring PRL levels intraoperatively may be a useful biomarker aiding surgeon's assessment of the extent of tumor resection and guide surgical decision-making. Further refinement of the immunoassay assay and clinical testing with more extensive prospective studies are needed.

In an overwhelming majority of patients with MEN1, radiological surveillance for non-functional pituitary adenomas offers minimal added benefit beyond patient-reported symptoms and pituitary function testing.

This case highlights the need to consider nonpituitary causes of acromegaly, especially in elderly patients with atypical biochemical or imaging findings. Non-pituitary causes of acromegaly should be considered in elderly patients with atypical biochemical profiles, as hepatic malignancy can rarely produce paraneoplastic IGF-1 excess even in the presence of incidental pituitary lesions.

P=N/A, N=20, Recruiting, University of Cambridge | Not yet recruiting --> Recruiting

P=N/A, N=20, Not yet recruiting, West China Hospital