prednisolone

He responded poorly to cytotoxic drugs, but achieved a durable complete remission with three cycles of oral prednisolone...However, he achieved complete remission with a combination of oral methotrexate and vincristine...There is no universal standard guideline for managing Rosai-Dorfman disease. However, patients with symptomatic disease, those experiencing emergency symptoms, and cases of relapse will require medical or surgical intervention to improve their outcomes.

P=N/A, N=124, Completed, Cairo University | Recruiting --> Completed

P2/3, N=1124, Active, not recruiting, St. Anna Childrens Cancer Research Institute GmbH | Not yet recruiting --> Active, not recruiting

P=N/A, N=104, Recruiting, Post Graduate Institute of Medical Education and Research, Chandigarh | Trial completion date: Dec 2025 --> Feb 2027 | Trial primary completion date: Dec 2024 --> Jan 2027

P3, N=49, Completed, Ultragenyx Pharmaceutical Inc | Active, not recruiting --> Completed

P4, N=26, Completed, Oslo University Hospital HF | Not yet recruiting --> Completed

P3, N=56, Active, not recruiting, AbbVie | Trial completion date: Aug 2027 --> Aug 2028 | Trial primary completion date: Aug 2027 --> Aug 2028

P=N/A, N=30, Completed, Benha University

Her symptoms and endoscopic and radiologic abnormalities resolved after discontinuation of pembrolizumab and initiation of oral prednisolone, and steroids were successfully tapered without recurrence. This case highlights a rare but clinically important pattern of ICI-induced pan-airway mucositis, in which lower-airway inflammation may be initially attenuated by inhaled steroids and later become evident after extension to the upper airway; such airway irAEs should be considered in ICI-treated patients presenting with persistent or atypical upper-airway symptoms.

B-cell chronic lymphocytic leukemia (B-CLL) was diagnosed, which in cats is much less frequent than T-CLL. There was a favorable response to alkylating therapy, and the cat survived for 19 months.

Although optic nerve signal changes are an uncommon manifestation of giant cell arteritis (GCA), the neurology team commenced high-dose oral prednisolone (60 mg once daily), considering GCA in the differential diagnosis...Subsequent temporal artery ultrasound findings were consistent with GCA, supporting the diagnosis. This case highlights an unusual radiological presentation of GCA and underscores the importance of early empirical treatment to prevent irreversible visual complications.

P1, N=141, Active, not recruiting, EMD Serono Research & Development Institute, Inc. | Recruiting --> Active, not recruiting