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    DRUG:

    prednisone

    Company:
    Generic mfg.
    Drug class:
    Steroid receptor agonist
    Related drugs:
    22h
    EvoPAR-PR02: A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation (clinicaltrials.gov)
    P3, N=700, Recruiting, AstraZeneca
    Trial initiation date
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • BRCA (Breast cancer early onset)
    |
    BRCA2 mutation • BRCA1 mutation
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    abiraterone acetate • prednisone • saruparib (AZD5305)
    1d
    Clinical Study to Assess the Efficacy and Safety of Olaparib in Chinese Patients With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Prior Treatment With a New Hormonal Agent and Have BRCA1/2 Mutations (clinicaltrials.gov)
    P4, N=43, Active, not recruiting, AstraZeneca | Completed --> Active, not recruiting | Trial completion date: Jul 2025 --> Dec 2026
    Enrollment closed • Trial completion date
    |
    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset)
    |
    BRCA2 mutation • BRCA1 mutation
    |
    Lynparza (olaparib) • Xtandi (enzalutamide) • abiraterone acetate • prednisone
    2d
    Phase I Trial of Apalutamide Plus Abiraterone Acetate, Docetaxel, and Prednisone in Patients With mCRPC (clinicaltrials.gov)
    P1, N=16, Completed, Weill Medical College of Cornell University | Active, not recruiting --> Completed | Trial completion date: Oct 2026 --> Oct 2025
    Trial completion • Trial completion date
    |
    CELLSEARCH®
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    docetaxel • abiraterone acetate • prednisone • apalutamide
    5d
    Case Report: Prostate adenocarcinoma with peritoneal carcinomatosis and elevated CEA mimicking colorectal cancer: a diagnostic dilemma. (PubMed, Front Oncol)
    He achieved an excellent response to androgen deprivation therapy (ADT) combined with abiraterone and prednisone, maintaining an undetectable prostate-specific antigen (PSA) level for over 2 years...The patient transitioned to docetaxel plus ADT, resulting in symptomatic improvement and partial radiologic response...Second, standard markers such as PSA and immunohistochemistry may be misleading in atypical presentations. Finally, the case highlights the decisive role of molecular diagnostics, specifically NGS, in identifying tumor origin and preventing misdiagnosis.
    Journal
    |
    CEACAM5 (CEA Cell Adhesion Molecule 5) • ERG (ETS Transcription Factor ERG) • TMPRSS2 (Transmembrane serine protease 2)
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    docetaxel • 5-fluorouracil • abiraterone acetate • prednisone • leucovorin calcium
    5d
    Matching-Adjusted Indirect Comparisons of PARP Inhibitor Combinations in Metastatic Castration-Resistant Prostate Cancer Across Key Populations. (PubMed, Oncologist)
    MAICs showed improved clinical benefit with TALA+ENZA versus OLAP+AAP and NIRA+AAP across multiple mCRPC populations and endpoints. Despite limitations of indirect comparisons, findings support TALA+ENZA as a first-line treatment option for mCRPC.
    Journal • BRCA Biomarker • PARP Biomarker
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    HRD (Homologous Recombination Deficiency) • BRCA (Breast cancer early onset)
    |
    BRCA mutation
    |
    Lynparza (olaparib) • Talzenna (talazoparib) • Zejula (niraparib) • Xtandi (enzalutamide) • abiraterone acetate • prednisone
    5d
    Aclarubicin Plus Cyclophosphamide, Vincristine, and Prednisone (CAOP) in Patients With Previously Treated Cutaneous T-cell Lymphoma (clinicaltrials.gov)
    P1/2, N=37, Not yet recruiting, Shanghai Jiao Tong University School of Medicine
    New P1/2 trial
    |
    cyclophosphamide • vincristine • prednisone • aclarubicin
    5d
    Aclarubicin Plus Cyclophosphamide, Vincristine, and Prednisone (CAOP) in Patients With Previously Untreated Peripheral T-Cell Lymphoma (clinicaltrials.gov)
    P2, N=36, Not yet recruiting, Shanghai Jiao Tong University School of Medicine
    New P2 trial
    |
    TNFRSF8 (TNF Receptor Superfamily Member 8)
    |
    ALK negative
    |
    cyclophosphamide • vincristine • prednisone • aclarubicin
    5d
    LORIKEET: A Study of Lorigerlimab With Docetaxel or Docetaxel Alone in Participants With Metastatic Castration-Resistant Prostate Cancer (clinicaltrials.gov)
    P2, N=154, Completed, MacroGenics | Active, not recruiting --> Completed
    Trial completion
    |
    BRCA (Breast cancer early onset)
    |
    BRCA mutation
    |
    docetaxel • prednisone • lorigerlimab (MGD019)
    6d
    Case Report: The diagnostic and therapeutic crossroads: when myelofibrosis transforms into mixed phenotype acute leukemia. (PubMed, Front Oncol)
    Given the patient's advanced age and underlying MF, two cycles of a low-intensity chemotherapy regimen primarily based on the "VP regimen (Vincristine + Prednisone) combined with Azacitidine" were administered...Patient tolerability to intensive chemotherapy and novel targeted agents (e.g., Venetoclax) is poor, leading to a dismal prognosis...This case not only serves as a unique model illustrating the complex evolution of a malignant clone but also profoundly reveals the unique therapeutic challenges and extremely poor survival outcome resulting from the convergence of advanced age, MF background, and MPAL transformation. It offers pivotal real-world evidence for the clinical management of this specific patient population and highlights the need to explore novel therapeutic strategies.
    Journal
    |
    NRAS (Neuroblastoma RAS viral oncogene homolog) • KIT (KIT proto-oncogene, receptor tyrosine kinase) • JAK2 (Janus kinase 2) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • CD34 (CD34 molecule) • CD7 (CD7 Molecule)
    |
    ASXL1 mutation • TET2 mutation • EZH2 mutation
    |
    Venclexta (venetoclax) • azacitidine • vincristine • prednisone
    7d
    Abi/Pred + ADT vs ADT in PSMA-Positive, Conventionally Node-Negative Prostate Cancer (clinicaltrials.gov)
    P2, N=140, Recruiting, University of Nebraska | Not yet recruiting --> Recruiting
    Enrollment open
    |
    abiraterone acetate • prednisone
    7d
    ZUMA-23: Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma (clinicaltrials.gov)
    P3, N=300, Active, not recruiting, Kite, A Gilead Company | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • Yescarta (axicabtagene ciloleucel) • prednisone • fludarabine IV
    8d
    Central nervous system post-transplant lymphoproliferative disorder relapse after pediatric liver transplantation: a case report and literature review. (PubMed, Transl Pediatr)
    Therefore, we upgraded the treatment plan to R-CHOP chemotherapy (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone), and achieved a complete remission (CR)...We observe that the combination of HD-MTX and intrathecal chemotherapy exhibits remarkable efficacy in managing post-transplant CNS-PTLD that is resistant to conventional R-CHOP chemotherapy. CAR-T therapy emerges as a potential option for patients suffering from relapsed or refractory CNS-PTLD.
    Journal
    |
    CD20 (Membrane Spanning 4-Domains A1)
    |
    CD20 positive
    |
    Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • methotrexate IV