P2, N=40, Active, not recruiting, Federal University of São Paulo | Recruiting --> Active, not recruiting | Trial completion date: Nov 2025 --> Nov 2026

P2, N=118, Not yet recruiting, Daré Bioscience, Inc.

Intraoperative UTI attenuates postoperative CRP and ALT elevation, reflecting anti-inflammatory and partial hepatoprotective effects. Integration of UTI into comprehensive perioperative management may enhance clinical recovery.

P1, N=21, Recruiting, University of Wisconsin, Madison | Trial completion date: Jun 2026 --> Jun 2027 | Trial primary completion date: Jun 2026 --> Jun 2027

P1/2, N=76, Recruiting, Medical University of South Carolina | Trial completion date: May 2027 --> May 2028 | Trial primary completion date: May 2026 --> May 2027

P=N/A, N=350, Recruiting, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical College, Huazhong University o

P=N/A, N=1370, Not yet recruiting, Beijing Tiantan Hospital

Compared to those in the control group, the average daily egg production, eggshell thickness, oviduct weight, oviduct index, and the levels of luteinizing hormone, progesterone, and follicle-stimulating hormone were significantly higher in the Pal group...Furthermore, metabolomics analysis revealed that the levels of metabolites such as ritonavir, nicotinate riboside, and inosine were upregulated in the Pal group...These findings indicated that dietary Pal supplementation enhanced the production performance, antioxidant capacity, anti-inflammatory response, and reproductive function of laying hens. Therefore, these findings lay the foundation for the development of strategies and protocols for the inclusion of Pal in the diet of laying hens.

UTI confers broad and integrated protection of the intestine during sepsis. These findings suggest that IL-1β-mediated inflammatory signaling plays a key role in UTI-induced enteric neuroprotection and restoration of intestinal motility.

Drug screening identified the HIV protease inhibitor nelfinavir as a specific disruptor of the NIBAN2-FLII complex...Collectively, this study, for the first time, reveals that NIBAN2 maintains GSCs stemness by activating FLII-RREB1 axis and TLR3 signaling, thereby establishing a feed-forward signaling-transcription-metabolism axis. This finding provides a novel strategy and potential targets for precise therapeutic intervention against glioma stemness.

P3, N=348, Completed, Tata Memorial Hospital | Active, not recruiting --> Completed

In some cell lines, the fiber modification F5RGD10(2C) or verapamil treatment further improves actual spread efficiency. Nelfinavir inhibits spread and plaque formation of oncolytic adenoviruses with the 19KSS-iLQ125Ter modifications, irrespective of adenovirus death protein (ADP) expression...We identified an insertion site downstream of the L3-23K region that supports relatively high hPH20 activity while preserving the enhanced oncolytic potency of the virus. Combining 19KSS-iLQ125Ter with hPH20 expression may potentially improve therapeutic benefit in glioma.