P=N/A, N=42, Recruiting, London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Not yet recruiting --> Recruiting | Trial completion date: May 2026 --> Apr 2027 | Initiation date: Mar 2026 --> Jun 2026 | Trial primary completion date: May 2026 --> Dec 2026

P=N/A, N=80, Completed, Fayoum University | Recruiting --> Completed | Trial completion date: May 2025 --> Jun 2026 | Trial primary completion date: Apr 2025 --> May 2026

Interventions targeting astrocyte phenotypes, including minocycline and Lcn2 knockdown, normalized the posterior piriform cortex neurochemistry and alleviated both nociceptive and affective symptoms. These findings define a mechanistic framework in which astrocytic dysfunction orchestrates pain and depression, and highlight astrocyte-directed strategies for treating cancer pain-depression comorbidity.

Two dominant H. pylori molecular states were identified: a virulence-competent Colonizer profile (127/158, 80.4%) enriched for cagA/vacA gene carriage and expression (q < 0.001), and a putative Resistant Inflammatory profile (31/158, 19.6%) characterized by elevated iceA expression (q = 0.002) and clarithromycin resistance mutations (q = 0.022), with reduced cagA/vacA (q < 0.001)...Integrated profiling suggests that H. pylori adopts distinct molecular states in gastric cancer associated with specific clinicopathological features. These findings support systems-level microbial characterization as a hypothesis-generating framework for exploring whether microbial molecular states may contribute to future risk stratification and eradication strategies in AMR-endemic regions, pending functional and external validation.

The results indicate that the palladium (II) complex is more potent than the ligand against the tested microorganisms, especially against K. pneumoniae, where it demonstrated promising activity that, upon further research, could be used to overcome gentamicin resistance...The interactions at the docking active sites were assessed using the chosen proteins, EGFR tyrosine kinase, and the protein crystal structure of GlcN-O-P synthase. The anti-inflammatory effect results indicated that both compounds have a moderate effect on bovine serum albumin (BSA).

Therefore, this platform is particularly suited for the treatment of FLT3-ITD AML while potentially applicable to other AML subtypes with high CD71 expression. By enabling specific intracellular accumulation of HHT and multitarget inhibition of FLT3 signaling pathways, this system achieves enhanced anti-AML efficacy both in vitro and in vivo, offering strong potential for future clinical translation.

P1/2, N=12, Not yet recruiting, Centre Hospitalier De Versailles

Our study delineates a coherent and novel anti-leukemic pathway: TSN suppresses AML by directly targeting DDX5 for degradation, thereby inhibiting the pro-survival c-Myc axis. These findings elucidate the pharmacology of TSN and validate the DDX5/c-Myc axis as a promising therapeutic candidate in AML.

This was controlled with ultrasound-guided drainage (yielding approximately 3000 mL of old blood), debridement, and targeted antibiotic therapy (clindamycin). This case illustrates the rare yet complete clinical trajectory of spontaneous arterial rupture in NF1, from massive hematoma formation to infectious complications. It underscores that acute pain or an unexplained mass in an NF1 patient should raise immediate suspicion for spontaneous hemorrhage, necessitating prompt vascular imaging and multidisciplinary intervention to improve outcomes.

The resulting nanoparticles were investigated in a refractory AML mouse model (AML1-ETO & C-KITD816V) with a high level of CXCR4 and in the t(8; 21)-positive AML cell line Kasumi-1. It was shown that E5-LNP@siAE effectively achieved RNAi of AML1-ETO and antagonism of CXCR4, thereby synergistically inducing effective multi-lineage differentiation, leading to significantly enhanced differentiation-post apoptotic responses of AML cells to homoharringtonine and remarkably prolonged survival in refractory AML mice.

P=N/A, N=80, Not yet recruiting, The First Affiliated Hospital of Xinxiang Medical College

The patient had a 5-year history of diabetes, managed with metformin...The patient was treated with a 10-week course of antibiotics, initially with intravenous ertapenem, later switched to oral linezolid...The treatment was well-tolerated. This case report aims to raise clinicians' awareness of sternoclavicular joint infections caused by Staphylococcus capitis and to highlight the importance of early diagnosis and individualized treatment strategies.