P3, N=2468, Recruiting, Assistance Publique - Hôpitaux de Paris | Trial completion date: Jan 2026 --> Jun 2027 | Trial primary completion date: Dec 2025 --> Jun 2027

P=N/A, N=1643, Active, not recruiting, University of Florida | Trial completion date: Dec 2025 --> Jul 2026 | Trial primary completion date: Dec 2025 --> Jul 2026

P=N/A, N=70, Not yet recruiting, The University of Sydney

Some studies have shown that aspirin can prevent the formation of pre-metastatic niches, and P2Y12 inhibitors, such as clopidogrel, reduce the incidence of metastases in animal models. In summary, platelets play an important role not only in hemostasis, but also in the development and progression of cancer, which makes them an important target in the context of both antithrombotic and anticancer therapy. Their activity and number affect the course of the disease, the response to treatment and the risk of thrombotic complications, which emphasizes the need for further research on their role in oncology.

DAPT with aspirin and clopidogrel is more conducive to enhancing postoperative cardiac and coagulation functions and reducing inflammation in TBAD patients.

P4, N=11086, Recruiting, Seoul National University Hospital | Trial completion date: Mar 2030 --> Dec 2031 | Trial primary completion date: Mar 2030 --> Dec 2028

P1, N=32, Completed, Viatris Innovation GmbH | Enrolling by invitation --> Completed

P3, N=1000, Recruiting, University of Texas Southwestern Medical Center | Not yet recruiting --> Recruiting

P4, N=528, Completed, Seoul National University Bundang Hospital | Active, not recruiting --> Completed | Trial completion date: Jul 2026 --> Dec 2025

No major adverse event was reported in the study. Conclusion Both ticagrelor and prasugrel showed anti-inflammatory effects, with ticagrelor showing statistically significant reductions in inflammatory markers, compared to prasugrel, in our study population.

P3, N=200, Recruiting, Kafrelsheikh University

P=N/A, N=110, Recruiting, Acibadem University