Rectal Cancer

P=N/A, N=1200, Not yet recruiting, Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Initiation date: Jan 2026 --> Jul 2026

P=N/A, N=0, Withdrawn, University of Colorado, Denver | N=200 --> 0 | Not yet recruiting --> Withdrawn

P=N/A, N=550, Recruiting, Assistance Publique - Hôpitaux de Paris | Not yet recruiting --> Recruiting

P=N/A, N=84, Recruiting, Althaia Xarxa Assistencial Universitària de Manresa

P2, N=49, Active, not recruiting, City of Hope Medical Center | Recruiting --> Active, not recruiting

NFYA promoted REG1A expression, and the NFYA-REG1A axis enhanced RC resistance to RT and CT and malignant progression.

P1, N=14, Active, not recruiting, City of Hope Medical Center | Recruiting --> Active, not recruiting

The preoperative fusion model significantly improves the accuracy of N-staging in rectal cancer. By outperforming manual interpretation and demonstrating encouraging preliminary generalizability in an external cohort, this model shows potential as a clinical aid for identifying patients who will benefit from neoadjuvant therapy, thereby facilitating personalized clinical decision-making and reducing interobserver variability.

P=N/A, N=0, Withdrawn, NHS Grampian | N=350 --> 0 | Active, not recruiting --> Withdrawn

Neoadjuvant treatment response in rectal cancer is dependent on genomic alterations, immune activation and stromal interactions. AI-driven biomarkers hold promise for personalized treatment and organ-preservation. Prospective, multicenter validation is essential to enable further clinical implementation.

This study suggests that multimodal prehabilitation influences basal immune function, leading to a less inflammatory state. However, as no significant differences in immune function were observed between prehabilitation and control groups on POD1, the impact of prehabilitation on postoperative immune function may be limited.

P=N/A, N=50, Recruiting, Centre Paul Strauss | Trial completion date: Sep 2025 --> Sep 2026 | Trial primary completion date: Sep 2025 --> Sep 2026