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DRUG:
Lynozyfic (linvoseltamab-gcpt)
i
Other names:
REGN5458, REGN 5458, BCMAxCD3 antibody, BCMAxCD3 bispecific antibody
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Associations
News
Trials
Company:
Regeneron
Drug class:
CD3 agonist, BCMA inhibitor
Related drugs:
‹
blinatumomab (53)
epcoritamab-bysp (11)
elranatamab-bcmm (8)
tebentafusp-tebn (7)
MGD006 (6)
BI 764532 (5)
tarlatamab-dlle (4)
SAR442257 (4)
AZD5863 (3)
CTIM-76 (3)
EX103 (3)
JNJ-5322 (3)
A-319 (2)
AMG 794 (2)
ASP2138 (2)
mosunetuzumab-axgb (2)
NVG-111 (2)
talquetamab-tgvs (2)
teclistamab-cqyv (2)
VIR-5818 (2)
CC-93269 (2)
IMC-F106C (2)
IGM-2323 (2)
AMV564 (2)
CLN-978 (1)
CT-95 (1)
glofitamab-gxbm (1)
GEN1047 (1)
ISB 1342 (1)
MGD024 (1)
odronextamab (1)
SAR443216 (1)
GNC-035 (1)
AMG 701 (1)
MK-4002 (1)
REGN4018 (1)
XmAb14045 (1)
JNJ-63898081 (1)
AMG 509 (1)
A-337 (0)
ABBV-184 (0)
ABBV-2001 (0)
ADG138 (0)
AFM11 (0)
AMG 211 (0)
AMG 305 (0)
AMG 562 (0)
ASP2074 (0)
AVC-001 (0)
BA1202 (0)
BC3448 (0)
BI 765049 (0)
BNT142 (0)
BS006 (0)
CBA-1535 (0)
CC-1 (0)
CCW702 (0)
CD30 biAb-AATC (0)
CLN-049 (0)
CM350 (0)
CND261 (0)
ERY974 (0)
TRBS07 (0)
F182112 (0)
GEM333 (0)
GEN1044 (0)
GEN3017 (0)
GNC-039 (0)
GNR-084 (0)
GSK5926371 (0)
HBM7004 (0)
HPN536 (0)
IBI-389 (0)
IGM-2537 (0)
IGM-2644 (0)
IO-312 (0)
ISB 1302 (0)
JANX008 (0)
JNJ-63709178 (0)
JNJ-67571244 (0)
JNJ-8543 (0)
JNJ-8902 (0)
JS203 (0)
catumaxomab (0)
LBL-033 (0)
FBTA05 (0)
M701 (0)
M802 (0)
MBS314 (0)
MP0533 (0)
NG-641 (0)
NGM936 (0)
NILK-2301 (0)
NILK-2501 (0)
NM28-2746 (0)
PF-06671008 (0)
PF-07062119 (0)
PF-07260437 (0)
PIT565 (0)
PRO-203 (0)
QLS31904 (0)
QLS31905 (0)
QLS32015 (0)
RG6007 (0)
RG6129 (0)
RG6232 (0)
RG6353 (0)
RGV004 (0)
SAIL66 (0)
SAR440234 (0)
TAK-186 (0)
TQB2825 (0)
TQB2934 (0)
UMG2-CD3 BTCE (0)
Undisclosed HER2Bi-armed ATC (0)
WVT078 (0)
XmAb968 (0)
Y150 (0)
AMG 160 (0)
activated CIK and bispecific antibody (0)
activated CIK-anti-CD3/MUC1/CEA/EpCAM/GPC3 antibody (0)
ZG006 (0)
ARB202 (0)
RG6160 (0)
RG7802 (0)
RG6524 (0)
AMG 330 (0)
AMG 673 (0)
GNC-038 (0)
ABBV-383 IV (0)
AMG 596 (0)
RG6234 (0)
MK-6070 (0)
AMG 910 (0)
huCD33-BsAb (0)
RG6286 (0)
APVO436 (0)
GD2xCD3 (0)
JNJ-6358 (0)
MGD009 (0)
AMG 420 (0)
JNJ-8343 (0)
XmAb13676 (0)
JNJ-8780 (0)
RG6194 (0)
AMG 110 (0)
AZD0486 (0)
MCLA-117 (0)
XmAb18087 (0)
AMG 199 (0)
REGN5459 (0)
CTX-8573 (1)
CDR101 (0)
FT576 (0)
RO7297089 (0)
SAR445514 (0)
blinatumomab (53)
epcoritamab-bysp (11)
elranatamab-bcmm (8)
tebentafusp-tebn (7)
MGD006 (6)
BI 764532 (5)
tarlatamab-dlle (4)
SAR442257 (4)
AZD5863 (3)
CTIM-76 (3)
EX103 (3)
JNJ-5322 (3)
A-319 (2)
AMG 794 (2)
ASP2138 (2)
mosunetuzumab-axgb (2)
NVG-111 (2)
talquetamab-tgvs (2)
teclistamab-cqyv (2)
VIR-5818 (2)
CC-93269 (2)
IMC-F106C (2)
IGM-2323 (2)
AMV564 (2)
CLN-978 (1)
CT-95 (1)
glofitamab-gxbm (1)
GEN1047 (1)
ISB 1342 (1)
MGD024 (1)
odronextamab (1)
SAR443216 (1)
GNC-035 (1)
AMG 701 (1)
MK-4002 (1)
REGN4018 (1)
XmAb14045 (1)
JNJ-63898081 (1)
AMG 509 (1)
A-337 (0)
ABBV-184 (0)
ABBV-2001 (0)
ADG138 (0)
AFM11 (0)
AMG 211 (0)
AMG 305 (0)
AMG 562 (0)
ASP2074 (0)
AVC-001 (0)
BA1202 (0)
BC3448 (0)
BI 765049 (0)
BNT142 (0)
BS006 (0)
CBA-1535 (0)
CC-1 (0)
CCW702 (0)
CD30 biAb-AATC (0)
CLN-049 (0)
CM350 (0)
CND261 (0)
ERY974 (0)
TRBS07 (0)
F182112 (0)
GEM333 (0)
GEN1044 (0)
GEN3017 (0)
GNC-039 (0)
GNR-084 (0)
GSK5926371 (0)
HBM7004 (0)
HPN536 (0)
IBI-389 (0)
IGM-2537 (0)
IGM-2644 (0)
IO-312 (0)
ISB 1302 (0)
JANX008 (0)
JNJ-63709178 (0)
JNJ-67571244 (0)
JNJ-8543 (0)
JNJ-8902 (0)
JS203 (0)
catumaxomab (0)
LBL-033 (0)
FBTA05 (0)
M701 (0)
M802 (0)
MBS314 (0)
MP0533 (0)
NG-641 (0)
NGM936 (0)
NILK-2301 (0)
NILK-2501 (0)
NM28-2746 (0)
PF-06671008 (0)
PF-07062119 (0)
PF-07260437 (0)
PIT565 (0)
PRO-203 (0)
QLS31904 (0)
QLS31905 (0)
QLS32015 (0)
RG6007 (0)
RG6129 (0)
RG6232 (0)
RG6353 (0)
RGV004 (0)
SAIL66 (0)
SAR440234 (0)
TAK-186 (0)
TQB2825 (0)
TQB2934 (0)
UMG2-CD3 BTCE (0)
Undisclosed HER2Bi-armed ATC (0)
WVT078 (0)
XmAb968 (0)
Y150 (0)
AMG 160 (0)
activated CIK and bispecific antibody (0)
activated CIK-anti-CD3/MUC1/CEA/EpCAM/GPC3 antibody (0)
ZG006 (0)
ARB202 (0)
RG6160 (0)
RG7802 (0)
RG6524 (0)
AMG 330 (0)
AMG 673 (0)
GNC-038 (0)
ABBV-383 IV (0)
AMG 596 (0)
RG6234 (0)
MK-6070 (0)
AMG 910 (0)
huCD33-BsAb (0)
RG6286 (0)
APVO436 (0)
GD2xCD3 (0)
JNJ-6358 (0)
MGD009 (0)
AMG 420 (0)
JNJ-8343 (0)
XmAb13676 (0)
JNJ-8780 (0)
RG6194 (0)
AMG 110 (0)
AZD0486 (0)
MCLA-117 (0)
XmAb18087 (0)
AMG 199 (0)
REGN5459 (0)
CTX-8573 (1)
CDR101 (0)
FT576 (0)
RO7297089 (0)
SAR445514 (0)
›
Associations
News
Trials
Filter by
Latest
1d
LINKER-MM5: A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM) (clinicaltrials.gov)
P3, N=915, Recruiting, Regeneron Pharmaceuticals
1 day ago
Trial initiation date
|
bortezomib • carfilzomib • dexamethasone • pomalidomide • Darzalex Faspro (daratumumab and hyaluronidase-fihj) • Lynozyfic (linvoseltamab-gcpt)
9d
A Trial to Study if REGN17372 in Combination With Linvoseltamab is Tolerable for Adult Participants With Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov)
P1/2, N=150, Recruiting, Regeneron Pharmaceuticals | Not yet recruiting --> Recruiting
9 days ago
Enrollment open • First-in-human
|
Lynozyfic (linvoseltamab-gcpt)
1m
EMN39: A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant (clinicaltrials.gov)
P3, N=1000, Recruiting, European Myeloma Network B.V.
1 month ago
Trial initiation date
|
lenalidomide • Darzalex (daratumumab) • dexamethasone • Lynozyfic (linvoseltamab-gcpt)
2ms
A Trial to Study if REGN17372 in Combination With Linvoseltamab is Tolerable for Adult Participants With Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov)
P1/2, N=150, Not yet recruiting, Regeneron Pharmaceuticals
2 months ago
New P1/2 trial • First-in-human
|
Lynozyfic (linvoseltamab-gcpt)
2ms
Response-Based Dose Reduction of Linvoseltamab in the Treatment of Relapsed, Refractory, or Triple-Class Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov)
P1/2, N=30, Recruiting, Fred Hutchinson Cancer Center | Not yet recruiting --> Recruiting
2 months ago
Enrollment open
|
Lynozyfic (linvoseltamab-gcpt)
2ms
LINKER-MM8: A Study of Linvo-VR vs DVRd in Transplant-Eligible Adult Participants With Newly Diagnosed Multiple Myeloma (NDMM) (clinicaltrials.gov)
P2/3, N=1570, Not yet recruiting, Regeneron Pharmaceuticals
2 months ago
New P2/3 trial
|
lenalidomide • bortezomib • Darzalex Faspro (daratumumab and hyaluronidase-fihj) • Lynozyfic (linvoseltamab-gcpt)
2ms
LINKER-SMM1: A Proof-of-Concept Trial to Study the Safety and Activity of Linvoseltamab in Participants With Smoldering Multiple Myeloma at High Risk of Developing Multiple Myeloma (clinicaltrials.gov)
P2, N=40, Active, not recruiting, Regeneron Pharmaceuticals | Recruiting --> Active, not recruiting
2 months ago
Enrollment closed
|
Lynozyfic (linvoseltamab-gcpt)
2ms
EMN39: A Randomized, Open-Label, Controlled Phase 3 Study Comparing Daratumumab, Lenalidomide and Dexamethasone Induction followed by Linvoseltamab Versus continued Daratumumab, Lenalidomide, and Dexamethasone in Newly Diagnosed Transplant Ineligible Multiple Myeloma Patients (2024-519827-16-00)
P2/3, N=713, Recruiting, European Myeloma Network B.V., Emn Trial Office S.r.l. Impresa Sociale
2 months ago
New P2/3 trial
|
lenalidomide • Darzalex (daratumumab) • dexamethasone • Lynozyfic (linvoseltamab-gcpt)
2ms
R5458-ONC-2246: A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy with Standard-of-Care Combination Regimens in Adult Participants with Relapsed/Refractory Multiple Myeloma (RRMM) (2024-519504-27-00)
P2/3, N=315, Not yet recruiting, Regeneron Pharmaceuticals Inc.
2 months ago
New P2/3 trial
|
bortezomib • Darzalex (daratumumab) • carfilzomib • dexamethasone • pomalidomide • Lynozyfic (linvoseltamab-gcpt)
3ms
LINKER-SMM2: A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM) (clinicaltrials.gov)
P3, N=270, Not yet recruiting, Regeneron Pharmaceuticals
3 months ago
New P3 trial
|
Darzalex Faspro (daratumumab and hyaluronidase-fihj) • Lynozyfic (linvoseltamab-gcpt)
3ms
BCMA Bispecific Antibody Therapy for Post-BCMA CAR T-Cell Therapy Relapse (RECLAIM) (clinicaltrials.gov)
P2, N=34, Not yet recruiting, Medical College of Wisconsin | Initiation date: Dec 2025 --> Mar 2026
3 months ago
Trial initiation date
|
Lynozyfic (linvoseltamab-gcpt)
3ms
LINKER-MM5: A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM) (clinicaltrials.gov)
P3, N=915, Recruiting, Regeneron Pharmaceuticals | Not yet recruiting --> Recruiting
3 months ago
Enrollment open
|
bortezomib • carfilzomib • dexamethasone • pomalidomide • Darzalex Faspro (daratumumab and hyaluronidase-fihj) • Lynozyfic (linvoseltamab-gcpt)
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