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    DRUG CLASS:

    Retinoic acid receptor agonist

    Related drugs:
    2d
    Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm (clinicaltrials.gov)
    P2, N=100, Enrolling by invitation, University of Nebraska | Trial completion date: Dec 2026 --> Dec 2027 | Trial primary completion date: Nov 2026 --> Jun 2027 | Not yet recruiting --> Enrolling by invitation
    Enrollment open • Trial completion date • Trial primary completion date
    8d
    Study to Assess Safety, Pharmacokinetics, and Treatment Effect of Cabtreo (clinicaltrials.gov)
    P4, N=100, Not yet recruiting, Bausch Health Americas, Inc.
    New P4 trial
    13d
    Chemical identification of the Viola phillipina extracts and their anti-acne activity: A comparison with isotretinoin and salicylic acid. (PubMed, Fitoterapia)
    Spearman correlation confirmed that anti-acne activity was positively correlated with synergistic effects of caffeic acid and 6,7-dihydroxycoumarin. In summary, Viola philippica extract exhibits promising multi-target anti-acne potential, supporting its development as a novel multifunctional treatment strategy.
    Journal
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    AR (Androgen receptor) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • TLR2 (Toll Like Receptor 2)
    14d
    The Clinical Efficacy and Mechanism of Action of Alitretinoin in the Treatment of Alopecia Areata. (PubMed, Ann Dermatol)
    Alitretinoin appears to be a safe and potentially effective treatment for patients with mild to moderate AA unresponsive to conventional therapies. Its role as a monotherapy or adjunctive option in selected cases warrants further investigation through larger controlled studies.
    Journal
    |
    IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • STAT3 (Signal Transducer And Activator Of Transcription 3)
    16d
    Clinical efficacy of chemopreventive agents in oral cancer and oral potentially malignant disorders: A systematic review. (PubMed, Oral Oncol)
    Herbal agents and combination therapies, such as those containing β-carotene, isotretinoin, IFN-α 2a, and vitamin E, have shown encouraging results, although the long-term benefits remain uncertain...While chemopreventive strategies offer potential, their clinical application remains limited by inconsistent outcomes and adverse effects. Advancing this field requires the development of targeted therapies, personalised approaches based on molecular profiling, and innovative delivery systems like nanocarriers to improve therapeutic efficacy and safety.
    Review • Journal
    |
    IFNA1 (Interferon Alpha 1)
    21d
    CHARM: Clindamycin Phosphate, Adapalene, and Benzoyl Peroxide Triple Combination Gel in Canadian Patients With Acne Vulgaris (clinicaltrials.gov)
    P=N/A, N=200, Active, not recruiting, Bausch Health Americas, Inc. | Recruiting --> Active, not recruiting
    Enrollment closed
    22d
    QUATRO-APL: Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic Leukemia (clinicaltrials.gov)
    P3, N=150, Recruiting, Quetzal Therapeutics
    New P3 trial
    |
    PML (Promyelocytic Leukemia)
    |
    Chr t(15;17)
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    Vesanoid (tretinoin) • arsenic trioxide
    1m
    Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm (clinicaltrials.gov)
    P2, N=100, Not yet recruiting, University of Nebraska
    New P2 trial
    1m
    Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Randomized Split-Face Study (clinicaltrials.gov)
    P2, N=40, Not yet recruiting, Assiut University
    New P2 trial
    2ms
    Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia (clinicaltrials.gov)
    P3, N=158, Active, not recruiting, Children's Oncology Group | Trial completion date: Sep 2025 --> Jun 2029
    Trial completion date
    |
    RARA (Retinoic Acid Receptor Alpha) • PML (Promyelocytic Leukemia)
    |
    cytarabine • idarubicin hydrochloride • mitoxantrone • Vesanoid (tretinoin) • arsenic trioxide • Hemady (dexamethasone tablets) • Starasid (cytarabine ocfosfate)
    2ms
    All-Trans Retinoic Acid (ATRA) and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer (clinicaltrials.gov)
    P1, N=18, Active, not recruiting, Dwight Owen | Trial completion date: Jan 2026 --> Dec 2026
    Trial completion date
    |
    PD-L1 (Programmed death ligand 1) • ALK (Anaplastic lymphoma kinase)
    |
    Tecentriq (atezolizumab) • Vesanoid (tretinoin)
    3ms
    Comparison of Efficacy and Safety of Combined Red and Blue Light with Intense Pulsed Light (400-600 nm/800-1200 nm) Plus Isotretinoin or Doxycycline in the Treatment of Moderate-to-Severe Acne (ChiCTR2500107064)
    P=N/A, N=40, Completed, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushuhu Hospital); The Fourth Affiliated Hospital of Soochow University (Suzhou Dushuhu H | Not yet recruiting --> Completed
    Trial completion