Salivary Gland Cancer

<br><br><b></b> This study delineated the mutational spectrum of recurrent and/or metastatic SDC. Even in advanced disease, prognostically relevant mutations were identified, emphasizing the clinical importance of cancer genomic profiling tests.

Follow-up bronchoscopy and chest imaging at 1, 3, 9, 24, and 36 months demonstrated sustained complete response without recurrence or metastasis; site-directed mucosal biopsies at each visit showed no tumor cells. This case adds to the limited literature supporting bronchoscopic PDT as a potential initial local treatment option in carefully selected patients with localized low-grade endobronchial PMEC, particularly when airway preservation is desirable.

P2, N=37, Recruiting, Dana-Farber Cancer Institute | N=55 --> 37

The expression of RSF-1 and hSNF2H was high in ACC, which was closely related to tumor tissue type. RSF-1 and hSNF2H can promote proliferation and migration of ACC cells.

P2, N=174, Active, not recruiting, Mayo Clinic | Recruiting --> Active, not recruiting

This case shows the diagnostic complexity of synchronous AR + malignancies with overlapping metastatic profiles and emphasizes the need for integrated clinical, radiological, and pathological assessment to ensure optimal patient management. It highlights the need to biopsy metastatic bone lesions in cases of SDC-especially in older men-to rule out osseous metastases from more frequent carcinomas such as PCa.

These findings suggest PRAME as a promising immunotherapeutic and diagnostic target for salivary gland carcinomas, particularly through T-cell-based therapies already under investigation in other malignancies such as acute myeloid leukemia. Further preclinical studies are needed to validate the functional and therapeutic significance of PRAME, FOLR1, and CLDN18.2 in this context.

This is the first reported case of ovarian HGSC coexisting with SCC. Given its extreme rarity, standardized treatment strategies have not yet been established.

An accurate histological and immunohistochemical study was crucial to guide the differential diagnosis. Here we present the first case of palisading adenocarcinoma affecting the parotid gland to further enrich the literature and to shed additional light on this peculiar and recently investigated neoplastic entity.

Transoral robotic surgery may represent a safe, minimally invasive, and oncologically appropriate surgical option for carefully selected pediatric patients with tongue base mucoepidermoid carcinoma. Further multicenter studies are warranted to better define long-term oncologic and functional outcomes in this population.

P2, N=57, Completed, National Cancer Center Hospital East | Active, not recruiting --> Completed