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our Premium Content: News alerts, weekly reports and conference plannersDRUG:
SAR444200
i
Other names: SAR444200, SAR 444200, SAR-444200
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News alerts, weekly reports and conference planners
Company:
Sanofi
Drug class:
TCR modulator, GPC-3 inhibitor
Related drugs:
2ms
Identification and non-clinical characterization of SAR444200, a novel anti-GPC3 NANOBODY® T-cell engager, for the treatment of GPC3+ solid tumors. (PubMed, Mol Cancer Ther)
The highly potent and efficacious activity of SAR444200 in diverse models of GPC3+ tumors and the extremely wide tolerated dose range merits further development of this compound. Furthermore, NANOBODY®-based TCEs developed using an anti-TCRαβ moiety may have specific advantages for the development of TCEs.
Journal • IO biomarker
|
GPC3 (Glypican 3) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)
|
SAR444200
11ms
Dose Escalation and Expansion Study of SAR444200-based Regimen in Adult Participants With Advanced Solid Tumors (clinicaltrials.gov)
P1/2, N=33, Active, not recruiting, Sanofi | Recruiting --> Active, not recruiting | N=106 --> 33 | Trial completion date: Dec 2030 --> Dec 2025 | Trial primary completion date: Dec 2030 --> Dec 2025
Enrollment closed • Enrollment change • Trial completion date • Trial primary completion date
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ALK (Anaplastic lymphoma kinase) • GPC3 (Glypican 3)
|
GPC3 expression • GPC3 positive
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Tecentriq (atezolizumab) • SAR444200
almost2years
Dose Escalation and Expansion Study of SAR444200-based Regimen in Adult Participants With Advanced Solid Tumors (clinicaltrials.gov)
P1/2, N=106, Recruiting, Sanofi | Trial completion date: May 2030 --> Dec 2030 | Trial primary completion date: May 2030 --> Dec 2030
Trial completion date • Trial primary completion date • Metastases
|
ALK (Anaplastic lymphoma kinase) • GPC3 (Glypican 3)
|
GPC3 expression • GPC3 positive
|
Tecentriq (atezolizumab) • SAR444200
over2years
Phase I/II open-label study on an anti-GPC3 T cell engager, SAR444200, in patients with advanced solid tumors: Preliminary dose escalation results (ESMO 2023)
Conclusions These preliminary results from the first two DLs suggest that SAR444200 is tolerable at the tested DLs in patients with advanced solid tumors. Dose escalation continues at this time.
Clinical • P1/2 data • Metastases
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IFNG (Interferon, gamma) • IL6 (Interleukin 6) • GPC3 (Glypican 3)
|
GPC3 expression • GPC3 positive
|
SAR444200
over2years
Dose Escalation and Expansion Study of SAR444200 in Adult Participants With Advanced Solid Tumors (clinicaltrials.gov)
P1/2, N=106, Recruiting, Sanofi | Trial completion date: May 2029 --> May 2030 | Trial primary completion date: May 2029 --> May 2030
Trial completion date • Trial primary completion date • Metastases
|
GPC3 (Glypican 3)
|
GPC3 expression • GPC3 positive
|
Libtayo (cemiplimab-rwlc) • SAR444200
3years
Dose Escalation and Expansion Study of SAR444200 in Adult Participants With Advanced Solid Tumors (clinicaltrials.gov)
P1/2, N=106, Recruiting, Sanofi | Trial completion date: Feb 2028 --> May 2029 | Trial primary completion date: Feb 2028 --> May 2029
Trial completion date • Trial primary completion date
|
GPC3 (Glypican 3)
|
GPC3 expression • GPC3 positive
|
Libtayo (cemiplimab-rwlc) • SAR444200
over3years
Dose Escalation and Expansion Study of SAR444200 in Adult Participants With Advanced Solid Tumors (clinicaltrials.gov)
P1/2, N=106, Recruiting, Sanofi | Not yet recruiting --> Recruiting
Enrollment open
|
GPC3 (Glypican 3)
|
GPC3 expression • GPC3 positive
|
Libtayo (cemiplimab-rwlc) • SAR444200
over3years
Dose Escalation and Expansion Study of SAR444200 in Adult Participants With Advanced Solid Tumors (clinicaltrials.gov)
P1/2, N=106, Not yet recruiting, Sanofi
New P1/2 trial
|
GPC3 (Glypican 3)
|
GPC3 expression • GPC3 positive
|
Libtayo (cemiplimab-rwlc) • SAR444200
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