senl_BCMA

We explored the use of nanobody-based BCMA(S103) CAR-T cell therapy for R/R plasma cell myeloma (NCT04447573). The one-year OS rate was 61.1%, and PFS was 57.2%. BCMA CAR-T therapy, utilizing dual nanobody VHHs targeting BCMA, demonstrates a high overall response rate (ORR) and manageable safety profile in treating patients with R/R plasmacytic myeloma, including those with high-risk features such as extramedullary lesions, high-risk cytogenetic abnormalities, plasma cell leukemia, or anaplastic plasmacytoma.

P=N/A, N=50, Recruiting, Hebei Senlang Biotechnology Inc., Ltd. | Completed --> Recruiting | Trial completion date: Dec 2024 --> Dec 2027 | Trial primary completion date: Sep 2024 --> Sep 2027

P=N/A, N=42, Completed, Hebei Senlang Biotechnology Inc., Ltd. | Recruiting --> Completed

Methods Autologous peripheral blood lymphocytes were collected from patients, who subsequently underwent intravenous fludarabine (30mg/m2/d) and cyclophosphamide (300mg/m2/d) lymphodepletion chemotherapy from day-5 to day -3. Conclusions The clinical trial demonstrated that BCMA CAR-T therapy, composed of dual nanobody VHHs targeting BCMA (dVHHs), exhibits a high ORR with a manageable safety profile in treating R/R MM patients. This extends even to high-risk patients, such as those with extramedullary lesions, cytogenetics high-risk groups, and patients with plasma cell leukemia or anaplastic plasma cell tumor.

P=N/A, N=50, Recruiting, Hebei Senlang Biotechnology Inc., Ltd.