P2, N=100, Recruiting, University of Michigan | Not yet recruiting --> Recruiting

Cyclophosphamide treatment induces profound suppression of ribosomal biogenesis, cytoplasmic translation, mitochondrial oxidative phosphorylation, and Wnt-associated regenerative programs in hair matrix cells, indicating a functional metabolic arrest preceding overt epithelial cell loss...Topical venlafaxine and its active metabolite desvenlafaxine preserved follicular architecture, suppressed apoptosis, and restored hair shaft elongation in both mouse CIA models and human hair follicle organ culture. At single-cell resolution, venlafaxine reversed epithelial translational shutdown, reactivated differentiation and Wnt signaling programs, and attenuated fibroinflammatory remodeling, thereby restoring paracrine niche signaling and matrix cell proliferation. Collectively, these findings redefine CIA as a disorder characterized by coordinated epithelial functional arrest and dermal inflammatory remodeling and identify venlafaxine as a potential pharmacological strategy to mitigate chemotherapy-associated hair loss.

Pharmacological inhibition of RBMS1 with nortriptyline (NTP) significantly attenuated renal fibrosis in unilateral ureteral obstruction (UUO) mice. These results reveal an RBMS1/ANXA8/PI3K/AKT regulatory axis in renal fibrosis, highlighting RBMS1 as a potential therapeutic target.

P4, N=100, Recruiting, Wake Forest University Health Sciences | Trial completion date: May 2026 --> May 2027 | Trial primary completion date: May 2026 --> May 2027

P2, N=12, Recruiting, ConSynance Therapeutics | Not yet recruiting --> Recruiting

P3, N=680, Completed, Otsuka Pharmaceutical Development & Commercialization, Inc. | Active, not recruiting --> Completed

P3, N=315, Completed, Otsuka Pharmaceutical Development & Commercialization, Inc. | Active, not recruiting --> Completed

P1, N=40, Completed, Otsuka Pharmaceutical Development & Commercialization, Inc. | Recruiting --> Completed

P3, N=42, Recruiting, St. Joseph's Healthcare Hamilton | Not yet recruiting --> Recruiting

Moreover, when combined with LPA, amitriptyline curtailed Rho activation and the Rho-mediated cellular responses. (4) These results demonstrate that in astroglial cells, amitriptyline exerts a balanced action on LPA-activated receptors by enhancing the neuroprotective ERK1/2-CREB-BDNF signaling and dampening the potentially detrimental Rho-ROCK pathway, and suggest that this unique property may contribute to the antidepressant activity of the drug.

P1, N=17, Completed, Rutgers, The State University of New Jersey | Recruiting --> Completed | Trial completion date: Dec 2025 --> Sep 2025

P2, N=100, Not yet recruiting, University of Michigan