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    DRUG CLASS:

    Serotonin reuptake inhibitor

    Related drugs:
    1d
    MACS-2: Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related Cough (clinicaltrials.gov)
    P2, N=25, Recruiting, Mayo Clinic | Trial completion date: Dec 2025 --> Oct 2026 | Trial primary completion date: Dec 2025 --> Oct 2026
    Trial completion date • Trial primary completion date
    |
    amitriptyline
    1d
    MACS-1: Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough (clinicaltrials.gov)
    P2, N=50, Recruiting, Mayo Clinic | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
    |
    amitriptyline
    6d
    Different Transcutaneous Electrical Nerve Stimulation Modes in Pudendal Neuralgia Post-prostatectomy (clinicaltrials.gov)
    P=N/A, N=60, Completed, Cairo University
    New trial
    6d
    A Study of CSTI-500 in Patients With Prader-Willi Syndrome (clinicaltrials.gov)
    P2, N=12, Not yet recruiting, ConSynance Therapeutics
    New P2 trial
    14d
    I-COAP: Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain (clinicaltrials.gov)
    P2, N=200, Recruiting, Mayo Clinic | Trial completion date: Dec 2031 --> Dec 2029 | Trial primary completion date: Dec 2030 --> Jul 2029
    Trial completion date • Trial primary completion date
    14d
    The Effect of Peppermint Oil Aromatherapy on Pain, Functional Capacity and Cost in Fibromyalgia Patients (clinicaltrials.gov)
    P=N/A, N=175, Not yet recruiting, Bilecik Seyh Edebali Universitesi
    New trial
    15d
    MRP-HAND: Multiprofen-CC to Reduce Pain in Hand Arthritis (clinicaltrials.gov)
    P3, N=42, Not yet recruiting, McMaster University | Initiation date: Aug 2025 --> Jan 2026
    Trial initiation date
    |
    amitriptyline
    16d
    Home-based Transcranial Direct Current Stimulation (tDCS) Compared to Duloxetine: Non-inferiority Clinical Trial (FIBROSTIM) (clinicaltrials.gov)
    P=N/A, N=610, Recruiting, Hospital de Clinicas de Porto Alegre | Not yet recruiting --> Recruiting
    Enrollment open • Head-to-Head
    20d
    Aromatase inhibitors induce pain-like musculoskeletal symptoms in mice: behavioural, pharmacological and pathophysiological characterization. (PubMed, Br J Pharmacol)
    We characterized a relevant and translational mouse model of AIMSS to help exploring the cellular and molecular mechanisms of the pathophysiology of AIs toxicity.
    Preclinical • Journal
    |
    ER (Estrogen receptor)
    |
    ER positive
    |
    letrozole
    21d
    A Trial to Assess How Centanafadine Interacts With Stimulants in the Body (clinicaltrials.gov)
    P1, N=42, Not yet recruiting, Otsuka Pharmaceutical Development & Commercialization, Inc.
    New P1 trial
    21d
    A Narrative Review of the Efficacy of Acupuncture in Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients. (PubMed, J Evid Based Integr Med)
    Acupuncture outperformed pharmacotherapy (eg, duloxetine) in safety and patient-reported outcomes.ConclusionAcupuncture is a promising adjunctive therapy for CIPN, offering multimodal mechanisms and clinical benefits. Standardization of protocols and further high-quality RCTs are needed to strengthen evidence and guide integration into oncology care.
    Review • Journal
    |
    BDNF (Brain Derived Neurotrophic Factor)
    22d
    Repositioning serotonergic antagonists as therapeutic agents in gastric cancer: induction of apoptosis, inhibition of cell migration, and cell cycle arrest in AGS cells. (PubMed, Cytotechnology)
    Imipramine induced G1/S phase arrest, whereas tropisetron, ketanserin, and cyproheptadine increased the sub-G1 cell population. Gene expression analysis revealed decreased Bcl-2 and PCNA levels and increased Bax expression.These findings suggest the potential of tropisetron, imipramine, ketanserin, and cyproheptadine as repurposed therapeutic agents for gastric cancer.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • PCNA (Proliferating cell nuclear antigen) • SLC6A4 (Solute Carrier Family 6 Member 4)
    |
    imipramine