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ruzaltatug rezetecan (SHR-A2009)
i
Other names: SHR-A2009, SHRA2009, SHR A2009
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Company:
Jiangsu Hengrui Pharma
Drug class:
Topoisomerase I inhibitor, HER3-targeted antibody-drug conjugate
Related drugs:
3ms
A Study of SHR-A2009 Combined With Aumolertinib Versus Aumolertinib for First-line Treatment in EGFR-mutated, Advanced or Metastatic NSCLC (clinicaltrials.gov)
P3, N=576, Not yet recruiting, Suzhou Suncadia Biopharmaceuticals Co., Ltd.
New P3 trial
|
Ameile (aumolertinib) • ruzaltatug rezetecan (SHR-A2009)
11ms
A Study of SHR-A2009 Versus Platinum-based Chemotherapy in EGFR-mutated, Advanced or Metastatic NSCLC (clinicaltrials.gov)
P3, N=500, Recruiting, Suzhou Suncadia Biopharmaceuticals Co., Ltd. | Not yet recruiting --> Recruiting
Enrollment open
|
cisplatin • carboplatin • ruzaltatug rezetecan (SHR-A2009)
11ms
SHR-A2009-I-102: The Clinical Study of SHR-A2009 for Injection in Patients With Advanced Solid Tumors (clinicaltrials.gov)
P1, N=19, Completed, Suzhou Suncadia Biopharmaceuticals Co., Ltd. | Active, not recruiting --> Completed | Trial completion date: Jun 2026 --> Apr 2024 | Trial primary completion date: Jun 2025 --> Apr 2024
Trial completion • Trial completion date • Trial primary completion date
|
ruzaltatug rezetecan (SHR-A2009)
1year
Study of HRS-8080 or SHR-A2009 Combined With Anti-tumor Therapy in Patients With Unresectable or Metastatic Breast Cancer (clinicaltrials.gov)
P1/2, N=350, Recruiting, Shandong Suncadia Medicine Co., Ltd. | Not yet recruiting --> Recruiting
Enrollment open • Metastases
|
trastuzumab rezetecan (SHR-A1811) • AiRuiLi (adebrelimab) • ruzaltatug rezetecan (SHR-A2009)
1year
A Study of SHR-A2009 Versus Platinum-based Chemotherapy in EGFR-mutated, Advanced or Metastatic NSCLC (clinicaltrials.gov)
P3, N=500, Not yet recruiting, Suzhou Suncadia Biopharmaceuticals Co., Ltd.
New P3 trial • Metastases
|
cisplatin • carboplatin • ruzaltatug rezetecan (SHR-A2009)
1year
Platform Study of ADC Rechallenge in ADC-treated Metastatic Breast Cancer (clinicaltrials.gov)
P2, N=120, Recruiting, Fudan University
New P2 trial • Metastases
|
HER-2 (Human epidermal growth factor receptor 2) • NECTIN4 (Nectin Cell Adhesion Molecule 4) • TACSTD2 (Tumor Associated Calcium Signal Transducer 2)
|
HER-2 expression
|
trastuzumab rezetecan (SHR-A1811) • SHR-A2102 • ruzaltatug rezetecan (SHR-A2009) • tizetatug rezetecan (SHR-A1921)
1year
BCTOP-L-M05: SNF Platform Study of HR+/ HER2-advanced Breast Cancer (clinicaltrials.gov)
P2, N=620, Recruiting, Fudan University | N=140 --> 620
Enrollment change
|
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
|
ER positive • HR positive • HER-2 amplification • HER-2 negative • PGR positive • HER-2 negative + AR positive + ER positive • HER-2 negative + ER positive • HER-2 negative + PGR positive
|
Avastin (bevacizumab) • sorafenib • everolimus • AiRuiKa (camrelizumab) • AiTan (rivoceranib) • capecitabine • albumin-bound paclitaxel • fulvestrant • exemestane • trastuzumab rezetecan (SHR-A1811) • AiRuiYi (fluzoparib) • AiRuiKang (dalpiciclib) • goserelin acetate • famitinib (SHR 1020) • SHR-A2102 • ruzaltatug rezetecan (SHR-A2009) • tizetatug rezetecan (SHR-A1921)
1year
CAP 02: A Phase II Exploratory Clinical Trial of Multiple Drug Combinations in the Treatment of Advanced Esophageal Squamous Cell Carcinoma (clinicaltrials.gov)
P2, N=147, Recruiting, The First Affiliated Hospital of Zhengzhou University | Trial completion date: Dec 2024 --> Dec 2025
Trial completion date • Metastases
|
AiRuiKa (camrelizumab) • AiTan (rivoceranib) • AiRuiLi (adebrelimab) • ruzaltatug rezetecan (SHR-A2009)
over1year
A Phase IB/II Clinical Study of SHR-9839 for Injection Combined With Other Anti-tumor Therapies in Patients With Advanced Solid Tumors (clinicaltrials.gov)
P1/2, N=156, Not yet recruiting, Shanghai Hengrui Pharmaceutical Co., Ltd.
New P1/2 trial • Combination therapy • Metastases
|
carboplatin • pemetrexed • Ameile (aumolertinib) • ruzaltatug rezetecan (SHR-A2009) • tizetatug rezetecan (SHR-A1921)
over1year
Clinical Study of SHR-A1921 or SHR-A2009 in Previously Treated Advanced NSCLC (clinicaltrials.gov)
P2, N=30, Not yet recruiting, Henan Cancer Hospital
New P2 trial • Metastases
|
ruzaltatug rezetecan (SHR-A2009) • tizetatug rezetecan (SHR-A1921)
almost2years
Study of HRS-8080 or SHR-A2009 Combined With Anti-tumor Therapy in Patients With Unresectable or Metastatic Breast Cancer (clinicaltrials.gov)
P1/2, N=350, Not yet recruiting, Shandong Suncadia Medicine Co., Ltd.
New P1/2 trial • Metastases
|
trastuzumab rezetecan (SHR-A1811) • AiRuiLi (adebrelimab) • ruzaltatug rezetecan (SHR-A2009)
2years
A Phase IB/II Clinical Study of SHR-A2009 for Injection in Combination With Other Antitumor Therapies in Patients With Advanced Solid Tumors (clinicaltrials.gov)
P1/2, N=270, Not yet recruiting, Suzhou Suncadia Biopharmaceuticals Co., Ltd.
New P1/2 trial • Combination therapy • Metastases
|
Ameile (aumolertinib) • AiRuiLi (adebrelimab) • ruzaltatug rezetecan (SHR-A2009)
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