Spindle Cell Sarcoma

Notably, the presence of cartilage foci within a RMS-like neoplasm represents a strong clue to an underlining DICER1 alteration. The rarity of this presentation in the nasal fossa at this age, coupled with its implications for diagnosis, treatment, and familial screening, emphasizes the need for awareness of the morphology patterns of DICER1-associated neoplasms across diverse anatomical sites.

Immunohistochemical staining, crucial for characterizing soft-tissue tumor differentiation, revealed diffuse positivity for SOX10 and S100 protein, consistent with a primary nerve sheath tumor rather than metastatic disease. This case highlights the diagnostic challenge posed by FDG-avid lesions in patients with a history of malignancy, underscoring the importance of considering rare differential diagnoses and pursuing tissue diagnosis when imaging is equivocal or clinical presentation deviates from expected metastatic behavior.

This case presents the diagnostic challenges in ALK-positive neoplasms. Superficial soft tissue tumors associated with ALK include a heterogeneous group of lesions that may share similar morphological features. We believe that a generic term, ALK-Rearranged Superficial Mesenchymal Neoplasms (ARSMN), may serve as a more inclusive diagnostic label for these entities in routine pathology practice.

The expression of p75NTR has not been described in this tumour entity before and its significance with regard to tumour promoting or tumour suppressing function or indication of a neurogenic differentiation remains undetermined. After a 3-year follow-up the dog was clinically healthy, indicating a successful surgical treatment.

However, genetic sequencing identified the NRAS Q16R mutation both in the nodule and underlying congenital nevus, leading to the diagnosis of a proliferative nodule composed of poorly differentiated melanocytes. Despite the limited use of molecular biology in the diagnosis of atypical proliferative nodules, it may be helpful in some challenging cases.

LLTs should be considered in the differential diagnosis of vulvar soft tissue masses. Accurate histopathological and molecular evaluation, combined with appropriate surgical management, ensures favorable outcomes and helps avoid unnecessary interventions.

Surgical resection remains the mainstay of treatment. This case highlights the importance of including IMT in the differential diagnosis of atypical intra-abdominal masses and supports the role of advanced molecular techniques in improving diagnostic accuracy and management.

Their aggressive clinical behavior, combined with unique histopathological and genetic features, underscores the need for molecular testing to ensure accurate diagnosis. Tyrosine kinase inhibitors such as imatinib may hold therapeutic promise, but further research is needed to optimize treatment strategies.

A meticulous surgical approach is vital for the management of the balance of complete tumor excision and preservation of hand function. A thorough histopathological examination is necessary for diagnosis. Collaboration across disciplines is key to improving treatment outcomes.

The tumor was resected, and the patient remains stable at 7 months follow-up. This report is the first known case of a TRAF7-mutated myxoid and spindle cell tumor in a pediatric patient.

Despite the usefulness of liquid biopsy, rebiopsy should be executed whenever possible. Indeed, it remains the only tool for assessing histological transformation, which greatly impacts prognosis and treatment decisions.

Effects of siRNA-dependent ZEB1 knockdown on UM cell proliferation and their sensitivity to the VEGF-A inhibitor Eylea (aflibercept) were tested by MTT and in a real-time proliferation assay...In addition, there is probably a ZEB1 feedback loop that is sensitive to a drop in VEGF-A concentration. The data obtained allow us to consider ZEB1 silencing as an auxiliary link for a combined strategy of killing UM cells.