Spindle Cell Sarcoma

Recognition of gene fusion signatures not only enhances diagnostic precision but also opens avenues for targeted therapy in selected cases. Continued molecular investigation and case accumulation are necessary to validate the biological behavior and therapeutic implications of many of these newly recognized entities.

The patient underwent wide surgical excision with negative margins and recovered uneventfully. This case emphasizes the importance of maintaining synovial sarcoma in the differential diagnosis of deep thigh masses in older adults, where imaging and molecular confirmation are essential to avoid misdiagnosis and treatment delay.

These findings emphasize the need for standardized diagnostic protocols, including routine Rb evaluation and MDM2 analysis, to ensure accurate classification. Future studies should explore the significance of MDM2 expression in ASPLT and reassess its anatomic predilection to refine diagnostic criteria and clinical management strategies.

We report the first 3 cases of YAP1::TFE3-rearranged, nonvisceral inflammatory spindle cell PEComa occurring in somatic soft tissue sites, expanding the anatomic spectrum of this recently characterized entity. Inflammatory spindle cell PEComa should be considered in the differential diagnosis of spindle cell neoplasms with prominent admixed inflammation.

With the advent of immunohistochemistry, it is revealed that tumor cells in SFT lack mesothelial characteristics but express CD34 and Bcl-2, suggesting that the tumor originates from mesenchymal tissue. Preoperative definitive diagnosis of SFT cervix is difficult.

Based on these molecular findings, the diagnosis was confirmed as an NTRK-rearranged high-grade sarcoma with an unusual histomorphological phenotype. This case highlights novel molecular characteristics of NTRK-rearranged high-grade sarcoma and underscores the critical role of comprehensive molecular profiling in diagnosing challenging cases.

Although a causal relationship between excess growth hormone (GH) or insulin-like growth factor 1 (IGF-1) and schwannoma development cannot be established from a single case, this association is hypothesis-generating and highlights the need for careful head and neck evaluation in patients with endocrine disorders. The patient had an uneventful postoperative course, and no recurrence was observed at six-month follow-up.

Mohs micrographic surgery remains the preferred treatment, offering precise tumor margin control and minimizing recurrence risk compared to wide local excision, while systemic options such as imatinib are reserved for unresectable or metastatic disease. Early recognition and intervention are especially critical in older patients, given their higher risk of adverse outcomes.

As the first known case to date with this fusion, these findings contribute to the emerging research on genomic testing in acral soft tissue tumors. Additional cases and longer clinical follow-up are needed to better characterize the novel HMGA2::NCOA2 fusion.

Colonic LMS is a rare and aggressive tumor that often evades preoperative diagnosis, especially when biopsies are inconclusive. Surgical resection with negative margins is the mainstay of treatment, and close surveillance is essential due to the high risk of recurrence.

Stains for MDM2, CDK4, and caldesmon are negative. The case is notable for its atypical progression, as most dedifferentiated SFTs transition directly from a benign-appearing SFT to a high-grade component without signs of malignancy in the conventional SFT region.

HNSpCC is an aggressive malignancy with poor outcomes, especially in advanced-stage and oral cavity cases.