^
    3d
    Expanding the Spectrum of Ubiquitin-specific Proteases-Fused Neoplasms: A Clinicopathologic and Molecular Study of USP2- and USP8-Rearranged Spindle Cell Tumors. (PubMed, Am J Surg Pathol)
    They exhibit significant overlap with USP6-associated lesions and PDGFR-altered myofibromas. Recognizing these fusions is critical to avoid diagnostic pitfalls and overtreatment, particularly when they present in unusual sites, such as the heart.
    Journal
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    ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • CD34 (CD34 molecule) • USP6 (Ubiquitin Specific Peptidase 6)
    3d
    Pelvic Malignant Peripheral Nerve Sheath Tumor Revealing Previously Undiagnosed Familial Neurofibromatosis Type 1 in a Nine-Year-Old Girl: A Case Report. (PubMed, Cureus)
    The patient was started on doxorubicin and ifosfamide chemotherapy. This case emphasizes that systematic cutaneous assessment in children with deep, rapidly growing soft tissue masses can be pivotal for identifying NF1, refining the differential diagnosis toward MPNST, and accelerating appropriate staging and multidisciplinary management.
    Journal
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    NF1 (Neurofibromin 1) • SOX10 (SRY-Box 10) • CD99 (CD99 Molecule)
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    doxorubicin hydrochloride • ifosfamide
    3d
    A case of retroperitoneal malignant schwannoma in a young male: a case report. (PubMed, J Med Case Rep)
    This case underscores that a large, well-circumscribed retroperitoneal peripheral nerve sheath tumor in a young adult may still be malignant. Pathology-driven risk stratification with quantified mitotic activity and Ki-67 is essential for accurate classification and for planning structured post-resection surveillance.
    Journal
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    KIT (KIT proto-oncogene, receptor tyrosine kinase) • CD34 (CD34 molecule)
    10d
    ALK-Negative Systemic Anaplastic Large Cell Lymphoma With Multifocal Cutaneous Involvement Responding to Brentuximab Vedotin. (PubMed, Am J Dermatopathol)
    After a dose of ifosfamide/etoposide elsewhere, therapy was revised to ifosfamide, carboplatin, and etoposide plus brentuximab vedotin, with marked improvement by 2 cycles and cutaneous resolution by 5; she died of cardiopulmonary failure before the sixth cycle. This case underscores generous sampling, focused immunohistochemistry, and staging; negative ALK/EMA does not exclude systemic disease, and CD30-directed therapy can yield rapid cutaneous responses.
    Journal
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    ALK (Anaplastic lymphoma kinase) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C)
    |
    ALK positive • LDH elevation • ALK negative
    |
    carboplatin • ifosfamide • etoposide IV • Adcetris (brentuximab vedotin)
    10d
    Spindle Cell Rhabdomyosarcoma of Oral Cavity With TCF12::VGLL3 Fusion, Expanding on a Recently Described Entity With Digital Spatial Profiling and Long-Term Follow Up. (PubMed, Genes Chromosomes Cancer)
    No additional adjuvant treatment was given, and the patient is alive without disease, 8 months after the major resection. Long term follow-up of 6 years with only local recurrence lends further support to the notion that these neoplasms are a class of indolent/low-grade rhabdomyoblastic tumors that are biologically and clinically distinct from fully malignant spindle cell rhabdomyosarcomas.
    Journal
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    MYOD1 (Myogenic Differentiation 1) • PAX7 (Paired Box 7) • TCF12 (Transcription Factor 12) • VGLL3 (Vestigial Like Family Member 3)
    12d
    A rare case of sudden death due to hemorrhage in a gastrointestinal stromal tumor. (PubMed, J Forensic Sci)
    This case report highlights the importance and seriousness of GIST even when it falls in the low-risk category. In this case, GISTs presented with fatal upper gastrointestinal hemorrhage encountered during medico-legal autopsy in a case of sudden death.
    Journal
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    ANO1 (Anoctamin 1)
    15d
    Monophasic Synovial Sarcoma in an Adolescent: A Great Mimicker of Benign Pathology. (PubMed, J Indian Assoc Pediatr Surg)
    This case highlights the importance of maintaining a high index of suspicion for malignancy in deep-seated soft-tissue tumors. Early diagnosis, complete surgical removal, and multimodal therapy are crucial for the management of SS.
    Journal
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    BCL2 (B-cell CLL/lymphoma 2)
    16d
    Diagnostic Insights and Surgical Outcomes of Glomangiopericytoma: A Tertiary Center Case Series. (PubMed, J Rhinol)
    GPC is a rare and distinct vascular neoplasm characterized by perivascular spindle-cell proliferation and nuclear β-catenin expression. Endoscopic resection was the primary treatment modality in our cohort, and long-term surveillance remains essential because of the potential for delayed recurrence. This case series provides a descriptive overview of the clinical features, diagnostic approaches, and management of GPC.
    Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • STAT6 (Signal transducer and activator of transcription 6)
    16d
    Immunohistochemical and molecular profiling of uveal melanoma: clinicopathological correlations from an Italian cohort. (PubMed, Pathologica)
    This study highlights the heterogeneous molecular landscape of UM and underscores the importance of integrating histopathological and molecular data for improved prognostic stratification. The identification of potential therapeutic targets and atypical mutations typically associated with other melanoma subtypes suggests avenues for future research and tailored therapeutic strategies.
    Retrospective data • Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • BRAF (B-raf proto-oncogene) • ER (Estrogen receptor) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden) • PTEN (Phosphatase and tensin homolog) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • NOTCH1 (Notch 1) • GNAQ (G Protein Subunit Alpha Q) • KDR (Kinase insert domain receptor) • BAP1 (BRCA1 Associated Protein 1) • GNA11 (G Protein Subunit Alpha 11) • JAK3 (Janus Kinase 3) • H3-3A (H3.3 Histone A)
    |
    PD-L1 expression • TP53 mutation • TMB-H • BRAF mutation • PTEN mutation
    19d
    Primary Synovial Sarcoma of the Breast Initially Mimicking Dermatofibrosarcoma Protuberans: A Case Report. (PubMed, Eur J Breast Health)
    Surgical margins were negative, and one-year follow-up showed that the patient remained disease-free. This case highlights the importance of immunohistochemistry and molecular testing for accurate diagnosis and appropriate management.
    Journal
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    BCL2 (B-cell CLL/lymphoma 2) • CD34 (CD34 molecule) • SSX1 (SSX Family Member 1)
    22d
    Sarcomatoid carcinoma of the common bile duct: A case report and review of the literature. (PubMed, Int Cancer Conf J)
    Current literature indicates the widespread use of pancreaticoduodenectomy; while the role of chemotherapy remains unclear. The online version contains supplementary material available at 10.1007/s13691-026-00852-8.
    Journal
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    CA 19-9 (Cancer antigen 19-9)
    23d
    Highlighting a histopathological dilemma: atypical dermatofibrosarcoma protuberans diagnosed with multimodal dermoscopy. (PubMed, Skin Health Dis)
    Histopathology showed a monomorphic spindle-cell infiltrate without atypia; immunohistochemistry (IHC) confirmed a CD34-positive, S100-negative spindle-cell neoplasm consistent with a myxoid variant of dermatofibrosarcoma protuberans. This case highlights the diagnostic utility of multimodal dermoscopy integrated with histopathology and supportive IHC in precisely evaluating atypical cutaneous tumours.
    Journal
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    CD34 (CD34 molecule)