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    BIOMARKER:

    TBX1 overexpression

    i
    Other names: TBX1, T-Box Transcription Factor 1, T-Box Transcription Factor TBX1, Testis-Specific T-Box Protein, CATCH22, T-Box 1 Transcription Factor C, Velocardiofacial Syndrome, T-Box Protein 1, Brachyury, T-Box 1, TBX1C, CAFS, CTHM, DGCR, DORV, VCFS, TBX1, DGS, TGA, VCF
    Entrez ID:
    6899
    over2years
    TBX18 knockdown sensitizes esophageal squamous cell carcinoma to radiotherapy by blocking the CHN1/RhoA axis. (PubMed, Radiother Oncol)
    TBX18 knockdown lowered CHN1 transcription and thus reduced RhoA activity, which sensitized ESCC cells to radiotherapy.
    Journal
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    RHOA (Ras homolog family member A) • CHN1 (Chimerin 1) • TBX1 (T-Box Transcription Factor 1)
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    RHOA mutation • TBX1 overexpression
    over2years
    Sulforaphane Targets the TBX15/KIF2C Pathway to Repress Glycolysis and Cell Proliferation in Gastric Carcinoma Cells. (PubMed, Nutr Cancer)
    The anti-tumor effects of sulforaphane were antagonized by down-regulation of TBX15, up-regulation of KIF2C or addition of a PKM2 agonist. Sulforaphane can reduce cell proliferation and PKM2-mediated glycolysis in gastric carcinoma cells, apparently by activating the TBX15/KIF2C pathway.
    Journal
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    TBX1 (T-Box Transcription Factor 1) • KIF2C (Kinesin Family Member 2C) • PKM (Pyruvate Kinase M1/2) • TRPS1 (Transcriptional Repressor GATA Binding 1)
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    TBX1 overexpression
    over3years
    T-box transcription factor 19 promotes hepatocellular carcinoma metastasis through upregulating EGFR and RAC1. (PubMed, Oncogene)
    Besides, the combined application of EGFR inhibitor Erlotinib and RAC1 inhibitor NSC23766 markedly inhibited TBX19-mediated HCC metastasis. In conclusion, EGF/EGFR signaling upregulated TBX19 expression via ERK/NF-kB pathway and TBX19 fostered HCC metastasis by enhancing EGFR and RAC1 expression, which formed an EGF-TBX19-EGFR positive feedback loop. Targeting this signaling pathway may offer a potential therapeutic strategy to efficiently restrain TBX19-mediated HCC metastasis.
    Journal
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    EGFR (Epidermal growth factor receptor) • RAC1 (Rac Family Small GTPase 1) • TBX1 (T-Box Transcription Factor 1) • TCF19 (Transcription Factor 19)
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    EGFR positive • NFKB1 expression • TBX1 overexpression
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    erlotinib • NSC23766
    almost4years
    Establishment of the TBX-code reveals aberrantly activated T-box gene TBX3 in Hodgkin lymphoma. (PubMed, PLoS One)
    Taken together, we have revealed a lymphoid TBX-code and used it to identify an aberrant network around deregulated T-box gene TBX3 in HL which promotes hallmark aberrations of this disease. These findings provide a framework for future studies to evaluate deregulated T-box genes in lymphoid malignancies.
    Journal
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    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CD19 (CD19 Molecule) • TBX21 (T-Box Transcription Factor 21) • FOXC1 (Forkhead Box C1) • TBX1 (T-Box Transcription Factor 1)
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    TBX1 overexpression
    4years
    TBX15/miR-152/KIF2C pathway regulates breast cancer doxorubicin resistance via promoting PKM2 ubiquitination. (PubMed, Cancer Cell Int)
    Our data identify a new mechanism by which TBX15 abolishes DOX chemoresistance in breast cancer, and suggest that TBX15/miR-152/KIF2C axis is a novel signaling pathway for mediating DOX resistance in breast cancer through regulating PKM2 ubiquitination and decreasing PKM2 stability. This finding suggests new therapeutic target and/or novel strategy development for cancer treatment to overcome drug resistance in the future.
    Journal
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    TBX1 (T-Box Transcription Factor 1) • PKM (Pyruvate Kinase M1/2)
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    TBX1 overexpression
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    doxorubicin hydrochloride