temozolomide

Overall, our results elucidated that TEAD4-driven GPX8 suppresses mitochondrial oxidative stress in TMZ-resistant cells through activation of the CTHRC1/p38 MAPK/FOXO3 pathway, which promotes TMZ resistance in GBM cells. These findings suggest that GPX8 may serve as a novel therapeutic target for overcoming TMZ resistance in GBM.

During treatment with nivolumab, ipilimumab, cisplatin, and temozolomide, he developed multiple bluish macule-like lesions on the retroauricular region, neck, and anterior chest, surrounded by vitiligo-like halos. This case underscores the importance of biopsy for new pigmented lesions arising during melanoma immunotherapy. Recognizing tumoral melanosis is essential to avoid misinterpretation as disease progression and to guide appropriate clinical management.

This pathway promotes melanoma cell proliferation, migration, and resistance to temozolomide...These findings establish RPL18 as a key coordinator of melanoma progression by linking tumor-intrinsic pathways with microenvironmental regulation. Targeting the RPL18-BTF3-STAT3 axis may improve therapeutic responses in melanoma and other cancers with heightened STAT3 activity.

These findings indicated that DMC functions as an effective chemosensitizer, elevating TMZ efficacy. Combining DMC with DNA repair inhibitors may represent a promising therapeutic strategy to overcome resistance and improve IDH-wildtype grade diffuse glioma treatment outcomes.

P2, N=98, Not yet recruiting, Centre Hospitalier Universitaire de Besancon

In the first-line setting, targeted therapy and SSAs were associated with longer PFS than chemotherapy, with surufatinib and lanreotide showing favorable disease control. SDHx pathogenic variant status did not show a clear association with response to TKIs or temozolomide, underscoring the need for validation in larger cohorts.

Crucially, these effects were reversed by N-acetylcysteine (NAC), and lipid peroxidation was abrogated by the iron chelator deferoxamine (DFX), unequivocally confirming iron-dependent ferroptosis. Critically, cyst(e)inase synergized with temozolomide (TMZ), markedly enhancing its anti-tumor efficacy and prolonging survival, even in TMZ-resistant xenografts. These findings establish cysteine metabolism as a promising therapeutic target and position cyst(e)inase, especially with TMZ, as a potent strategy to overcome GBM resistance.

P=N/A, N=450, Recruiting, IRCCS San Raffaele | Trial completion date: Dec 2024 --> Dec 2026 | Trial primary completion date: Dec 2024 --> Dec 2026

P1, N=65, Active, not recruiting, Novartis Pharmaceuticals | Recruiting --> Active, not recruiting | Trial completion date: Jul 2026 --> Jul 2027

P1, N=60, Active, not recruiting, Northwestern University | Recruiting --> Active, not recruiting | Trial primary completion date: Feb 2027 --> Jan 2026

P2, N=606, Active, not recruiting, NRG Oncology | Trial completion date: Dec 2025 --> Dec 2026

P2, N=108, Recruiting, Tata Memorial Centre