Testicular Cancer

P=N/A, N=142, Not yet recruiting, University of Michigan Rogel Cancer Center | Trial completion date: Apr 2029 --> Aug 2029 | Initiation date: Apr 2026 --> Aug 2026 | Trial primary completion date: Apr 2029 --> Aug 2029

It also emphasizes that normal tumor marker levels do not exclude recurrence and that histopathological confirmation remains essential for accurate diagnosis. Recognition of unusual presentations in long-term survivors of germ cell tumors is important to facilitate timely diagnosis and appropriate management.

Our data indicate that DDX53 protein acts as a regulator of RNA metabolism in human cells. Collectively, we show that DDX53 participates in transcriptome regulation (including splicing) in male germ cells and exhibits transcriptomewide RNA interactions, but its wider biological role remains to be clarified.

Platinum-based chemotherapy remains the standard of care in this setting, administered either as conventional-dose cisplatin-based regimens or as high-dose carboplatin-based combination chemotherapy. In this narrative review, we outline established and emerging treatment opportunities for this rare but challenging clinical scenario of platinum-resistant GCCs. This review provides a focused and up-to-date synthesis of therapeutic options for multiply relapsed, platinum-refractory GCCs, with a particular emphasis on late-line treatment sequencing and emerging biomarker-driven strategies, including CLDN6-directed therapies.

A combined model utilising DWI, ADC, T2WI, and contrast-enhanced T1WI imaging, alongside AFP and cystic necrosis, demonstrates high precision, adaptability, and robustness in distinguishing seminoma from non-seminoma testicular tumors.

P2, N=798, Active, not recruiting, National Cancer Institute (NCI) | Trial primary completion date: May 2027 --> May 2026

P1, N=156, Recruiting, Context Therapeutics Inc. | N=80 --> 156 | Trial completion date: Apr 2028 --> Dec 2028 | Trial primary completion date: Apr 2027 --> May 2028

Anti-KLHL11 encephalitis mainly related to infratentorial encephalitis but can also present as limbic encephalitis and rarely as meningitis. Early diagnosis enables early oncological and immunologic treatment, hopefully improving outcomes.

Elevated biomarkers of gut microbial translocation, particularly sCD14, are associated with increased severity of CIPN in long-term GCT survivors. These findings support the hypothesis that treatment-related intestinal barrier disruption and subsequent immune activation may contribute to persistent neurotoxicity in cancer survivorship.

Serum miRNA levels represent a potential tool for differentiating UDT from RT. Our pilot/exploratory study partially corroborates this, but comprehensive prospective randomized trials with larger cohorts are essential to definitively clarify miRNA alterations for precise distinction.

Based on the anatomic location of the lesion restricted to the mediastinum testis and adjacent to the rete testis epithelium, the histopathologic features, and the immunohistochemical expression of vimentin and cytokeratin by the neoplastic cells, a diagnosis of carcinoma of the rete testis was established. Therefore, it is important to include this neoplasm as a rare differential diagnosis in bulls presenting with hemospermia or intratesticular cystic alterations.

P=N/A, N=55, Active, not recruiting, University of Southern California | Trial completion date: Aug 2027 --> Dec 2027 | Trial primary completion date: Aug 2026 --> Dec 2026