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    CANCER:

    Testicular Seminoma

    Related cancers:
    27d
    Single-cell analysis unravels divergent gene signatures shaping seminoma stemness and metastasis. (PubMed, Cell Death Discov)
    Based on these findings, we further developed a molecular panel to aid in the identification of seminomas with a higher risk of metastasis. In conclusion, our study identifies unique molecular signatures that facilitate risk stratification based on metastatic potential, providing valuable insights for improving precision medicine.
    Journal • Gene Signature
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    IFNG (Interferon, gamma)
    1m
    A Case of Spermatocytic Tumor of Testis. (PubMed, IJU Case Rep)
    We present a case of spermatocytic tumor, which is a distinct entity among testicular germ cell tumors, with a generally favorable prognosis following orchiectomy. However, long-term follow-up is recommended due to the potential for late metastasis.
    Journal
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    TNFRSF8 (TNF Receptor Superfamily Member 8) • ALPP (Alkaline Phosphatase, Placental) • SALL4 (Spalt Like Transcription Factor 4)
    1m
    A Case of Synchronous Bilateral Spermatocytic Tumor. (PubMed, IJU Case Rep)
    This rare case of synchronous bilateral spermatocytic tumor highlights the importance of considering this diagnosis in older men with bilateral testicular masses. Immunohistochemistry is essential for accurate identification.
    Journal
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    KIT (KIT proto-oncogene, receptor tyrosine kinase) • VIM (Vimentin) • SALL4 (Spalt Like Transcription Factor 4)
    1m
    Shared and compound-specific pathways of bisphenol A and its analogues in male infertility: An integrative approach combining network toxicology, omics analysis, and molecular docking. (PubMed, Reprod Toxicol)
    BPs may impair male fertility through shared BCL2-mediated apoptosis, with computational evidence suggesting compound-specific pathways involving CYP19A1 (steroidogenesis), AR (androgen signaling), and PTGS2 (inflammation). These findings underscore the need for compound-specific toxicological assessments integrating mechanistic and computational evidence to guide precise prevention and regulatory strategies.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)
    1m
    Molecular Characterization of Seminoma Utilizing the AACR Project GENIE: A Retrospective Observational Study. (PubMed, Cancers (Basel))
    This study provided a comprehensive molecular and genetic profiling of seminoma including key genetic alterations, affected pathways, and potential therapeutic strategies. Moreover, overlap between pathways and gene mutations provides the potential for alternative treatment options for seminoma via multiple pathways.
    Observational data • Retrospective data • Journal
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    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • ALK (Anaplastic lymphoma kinase) • AXL (AXL Receptor Tyrosine Kinase) • KMT2C (Lysine Methyltransferase 2C) • STAG2 (Stromal Antigen 2) • CCND2 (Cyclin D2) • PMS1 (PMS1 protein homolog 1) • BRD4 (Bromodomain Containing 4) • AMER1 (APC Membrane Recruitment Protein 1) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • H3-5 (H3.5 Histone)
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    KRAS mutation
    1m
    Immunophenotypic characteristics of mast cells in non-metastatic seminoma (PubMed, Arkh Patol)
    Immunophenotypic distribution of secretome granules indicates a decrease in the number of Tryptase-, Chymase- and CPA3-mast cells, which is inversely proportional to the pTNM stage of non-metastatic seminoma.
    Journal
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    CPA3 (Carboxypeptidase A3)
    1m
    Pathological and Clinical Implications of Tumor Microenvironment Evaluated With Multiplex Immunohistochemistry in Testicular Embryonal Carcinoma. (PubMed, Clin Genitourin Cancer)
    These findings highlight the relevance of TME in TGCT biology and prognosis. The observed associations suggest TME may influence tumor plasticity, metastatization and relapse risk, warranting validation in larger studies.
    Journal
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    CD20 (Membrane Spanning 4-Domains A1) • CD68 (CD68 Molecule)
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    cisplatin
    1m
    Therapeutic efficacy of sacituzumab govitecan in recurrent refractory germ cell tumors. (PubMed, Biomed Pharmacother)
    Our preclinical work on CDX and PDX together with proof-of-concept clinical case provide rationale for further studies. Refractory relapsing TGCTs represent another clinical entity for treatment with ADC-SG.
    Journal
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    TACSTD2 (Tumor Associated Calcium Signal Transducer 2)
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    cisplatin • Trodelvy (sacituzumab govitecan-hziy)
    1m
    MicroRNA-371a-3p Represents a Novel and Effective Diagnostic Marker for Testicular Germ Cell Tumours: A Real-World Prospective Comparison with Conventional Approaches. (PubMed, Pathophysiology)
    M371 showed excellent diagnostic performance, even for small tumours, supporting its clinical use. Further studies are needed to define its role in treatment planning and follow-up.
    Journal • Real-world evidence
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    AFP (Alpha-fetoprotein)
    1m
    Automated spatial analysis reveals proximity of human leukocyte antigen class I-positive tumor cells and CD8-positive cells of the tumor microenvironment in stage I seminoma. (PubMed, Pathol Res Pract)
    Seminoma cells expressing HLA class I tended to be located in close proximity to CD8-positive T cells, suggesting a spatial relationship that might influence the tumor immune microenvironment.
    Journal
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    CD8 (cluster of differentiation 8)
    1m
    Comprehensive analysis of microRNA expression provides mechanistic insights into transcriptomic alteration in primary and metastatic testicular germ cell tumors. (PubMed, Sci Rep)
    Target gene analysis implicated FOXO and RUNX1 regulation, somatotroph signaling, and height-related pathways. Overall, our comprehensive tissue-level miRNA profiling in TGCTs identified potential diagnostic biomarkers for histologic subtypes, offering insights into miRNA-mediated transcriptional dysregulation.
    Journal
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    RUNX1 (RUNX Family Transcription Factor 1) • DNMT3B (DNA Methyltransferase 3 Beta) • MIR200 (MicroRNA 200)
    1m
    Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors (clinicaltrials.gov)
    P1, N=44, Not yet recruiting, City of Hope Medical Center
    New P1 trial
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    cisplatin