Thyroid Gland Carcinoma

P=N/A, N=5000, Active, not recruiting, Brigham and Women's Hospital | Trial completion date: Mar 2026 --> Jun 2026

Early disease detection, achievement of disease-free status, and favorable postoperative biochemical markers are key predictors of survival in MTC. These findings underscore the importance of timely diagnosis and comprehensive management.

Given oncologic necessity, selpercatinib was reintroduced at a reduced dose (40 mg daily) without recurrence of severe transaminitis. This case highlights that selpercatinib can cause clinically significant hepatocellular DILI and underscores the diagnostic value of liver biopsy in distinguishing DILI from autoimmune hepatitis, particularly when considering safe dose modification and rechallenge.

IBC induces apoptosis and pyroptosis, with caspase-dependent Poly ADP-ribose Polymerase (PARP) and Gasdermin E (GSDME) cleavage simultaneously. This study reveals a novel function of IBC in inducing pyroptosis in tumor cells, expands its known pharmacological spectrum and highlights its value as a therapeutic agent for ATC.

This study identified that CHI3L1 was an oncogene in PTC and promotes tumor cell proliferation associated with downregulating the TP53 pathway. It provides new evidence supporting CHI3L1 as a potential molecular target for future therapeutic investigation in PTC.

Dynamic assessment of postoperative calcitonin kinetics enables meaningful stratification of recurrence risk among patients with medullary thyroid carcinoma and biochemical persistent disease. Incorporation of calcitonin-based growth kinetics may support more individualized postoperative surveillance strategies.

P2, N=25, Recruiting, Istituti Clinici Scientifici Maugeri SpA | Trial completion date: Dec 2027 --> Nov 2026

Because they require standardized gene-expression inputs and have not undergone prospective clinical validation, they should not be used as standalone tools for clinical diagnosis, risk stratification, or treatment decision-making. Overall, our findings identify candidate transcriptomic markers associated with PTC occurrence and lymph node metastasis and provide a basis for future translational evaluation.

This case highlights the diagnostic value of empiric high-dose radioiodine therapy combined with SPECT/CT in detecting occult metastases. Furthermore, the 11-year disease-free survival in our patient underscores that early identification and surgical resection of solitary brain metastases from PTC can lead to an exceptionally favorable long-term prognosis.

The overall survival period is currently around one year. Additionally, we provide a comprehensive review of the disease, emphasizing incidence and definition, clinical symptoms and prognosis, molecular characteristics and treatment of PDTC, which may offer valuable insights for clinical practitioners.

This case highlights the consideration of functioning metastases in persistent post-thyroidectomy thyrotoxicosis and demonstrates the potential effectiveness of RAI therapy when metastatic lesions retain iodine avidity. Oncogenic mutations such as HRAS may contribute to the pathophysiology of hormone-producing metastases and provide insights into tumor differentiation and therapeutic responsiveness.