TMB-H

Clinical data reflects this, with the mRNA vaccine mRNA-4157 (KEYNOTE-942) demonstrating a significant recurrence-free survival (RFS) benefit in the adjuvant setting...This reflects the logistical and biological complexities inherent in developing personalised vaccines, highlighting challenges in both manufacturing and subject recruitment. These remain key obstacles impeding the widespread clinical application of such vaccines.

We report a 69-year-old man with resectable stage IIB right upper lobe lung adenocarcinoma who received neoadjuvant pembrolizumab, carboplatin, and pemetrexed followed by robotic-assisted lobectomy. He received adjuvant pembrolizumab and daratumumab-CyBorD with partial hematologic response. This case highlighted that amyloid can unexpectedly be a second diagnosis after post-neoadjuvant lung resections and that proteomic subtyping is essential for prompt haematologic staging and treatment.

The findings of this research could facilitate early detection and propose possible therapeutic targets for HCC.

P2, N=30, Recruiting, ImmuneOncia Therapeutics Inc. | Trial primary completion date: Dec 2026 --> Jun 2027

Functional analysis in cell lines suggests poly (ADP-ribose) polymerase inhibitors and cytotoxic chemotherapy sensitivity in HRD and CN tumors, whereas immune features in MUT tumors support vulnerability to immunotherapy. These findings suggest that distinct hBC subtypes delineated by genomic instability can advance insights into molecular heterogeneity beyond expression-based classifications and support an integrative genomic instability index (HRD score, ploidy, size-stratified CN burden, and signature exposures) for patient stratification and personalized therapeutic strategies.

P2, N=880, Recruiting, Diwakar Davar | N=480 --> 880

Our study comprehensively reveals the cellular heterogeneity of palmitoylation, establishes a robust palmitoylation-related prognostic model, and identifies SEC61G as a promising therapeutic target in LUAD, offering a novel perspective for LUAD precision stratification and treatment studies.

P1/2, N=20, Recruiting, Merck Sharp & Dohme LLC | Initiation date: Mar 2026 --> Jun 2026

The validated CGP assay provides accurate, reproducible, and comprehensive detection of clinically relevant genomic alterations in solid tumors. These results support its suitability for routine clinical deployment, enabling reliable genomic profiling to inform precision oncology treatment decisions.

TMB appears significantly associated with aggressive clinicopathological features in GIST and serves as an independent prognostic marker. These findings suggest that TMB may hold potential for stratifying GIST patients who may require closer follow-up and more frequent surveillance.

The trial is registered on ClinicalTrials.gov with identifier NCT04591431 and in the European Union Drug Regulating Authorities Clinical Trials Database (EudraCT) with number 2018-002190-21. The competent authority, Agenzia Italiana del Farmaco (AIFA), authorized the trial on 8 July 2020 (AIFA/SC/P/76132).

The PREICO project suggests the feasibility of implementing a centralized CGP prescreening program in a public healthcare setting for tumor types without public NGS access. CGP identified potentially actionable alterations in a substantial proportion of patients across tumor types, informed treatment decisions and facilitated access to clinical trials in selected cases.