Tongue Carcinoma

P2, N=24, Recruiting, Memorial Sloan Kettering Cancer Center | Trial completion date: Jun 2026 --> Jun 2027 | Trial primary completion date: Jun 2026 --> Jun 2027

Delayed diagnosis is common due to low suspicion in "low-risk" individuals. This review underscores NSND OSCC as a unique entity requiring expanded risk assessment, heightened clinical vigilance for persistent oral lesions regardless of habit history, and targeted research into novel prevention and therapeutic strategies.

Mechanistically, DNPEP directly bound to the RACK1 protein, activating the ERK signaling pathway. DNPEP plays a critical role in TSCC progression and cisplatin resistance by interacting with RACK1 and activating ERK signaling, highlighting its potential as a therapeutic target to inhibit TSCC and overcome chemotherapy resistance.

 EpCAM overexpression was detected in approximately 28.6% of OSCC cases in this Northeast Indian cohort. The observed trends suggest increased EpCAM overexpression in males, those with alcohol consumption, and tongue carcinomas, while a significant association was observed with higher histological grade. This pilot study is limited by a small sample size and a lack of TNM staging and survival data, restricting prognostic interpretation. These findings should be considered preliminary and exploratory in nature. Larger prospective multi-centre studies are needed to validate these observations and determine the prognostic and therapeutic relevance of EpCAM in OSCC.

Although GLI1-altered neoplasms have a distinctive morphology, lack of defining immunophenotype makes molecular confirmation of GLI1-altered soft tissue tumors essential in most cases. These tumors are low-grade sarcomas which are treated with complete local excision and long-term follow-up.

18β-GRA exerts multi-faceted effects on SCC-9 cells, including growth inhibition, cell-cycle arrest, apoptosis induction, oxidative stress enhancement, and modulation of autophagy markers. The integrated proteomic and computational approach implicates several key pathways and protein targets in the anti-TSCC activity of 18β-GRA, providing a broader molecular context for its mechanistic understanding.

Furthermore, the 5-week APW treatment significantly reduced tumor growth and angiogenesis without evident hepatic or renal toxicity in Cal-27 xenograft-bearing mice. In conclusion, APW exerted potent anti-tumor effects by targeting both the Wnt/β-catenin pathway and mitochondrial apoptotic machinery, suggesting the great potential of APW as an adjuvant therapeutic candidate for TSCC treatment.

P=N/A, N=40, Recruiting, University of Michigan | Trial completion date: Jun 2026 --> Jun 2028 | Trial primary completion date: Jan 2026 --> Jan 2028

Pretreatment with the specific JNK inhibitor SP600125 reversed the increases cleaved PARP and caspase-3/-7 caused by gelsemine...The results of the present study collectively suggested that gelsemine induces apoptosis through a ROS- and JNK1/2 -co-regulated pathway. To the best of our knowledge, this study is the first to demonstrate that gelsemine may be a potential therapeutic agent for tongue SCC.

Furthermore, the drug efflux transporter ABCC1 is co-expressed with SNAI2, and miR-203a-mediated inhibition of SNAI2 reduced ABCC1 expression, leading to increased cisplatin accumulation, DNA damage, and cell death. Collectively, our findings reveal a KLF5-miR-203a-SNAI2 regulatory axis that modulates EMT and chemoresistance in TSCC, highlighting a potential therapeutic approach to overcome cisplatin resistance.

Importantly, combining T-mB7-1 with systemic CTLA-4 blockade markedly prolonged survival of mice harboring orthotopic KLN205-MUC1 tumors, with all treated mice surviving beyond 80 days in the otherwise fatal model. These findings demonstrate that soluble B7-1-expressing oncolytic HSV-1 combined with CTLA-4 blockade durably suppresses lymph node metastasis, providing a promising and minimally invasive strategy for regionally metastatic OSCC.

The patient remained disease-free 5 years after surgery. This case highlights the diagnostic importance of integrating histopathology, immunoprofiling, and molecular analysis in patients with rare salivary gland tumors and underscores the favorable outcomes of complete surgical resection for HCCC of the tongue.