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    DRUG:

    Anxu (rovadicitinib)

    i
    Other names: TQ05105, Q05105, Q 05105, TQ 05105, Q-05105, TQ-05105
    Associations

    News

    Trials
    Company:
    Sanofi, Sino Biopharm
    Drug class:
    JAK inhibitor, ROCK inhibitor, ROCK2 inhibitor
    Related drugs:
    Associations

    News

    Trials
    2ms
    A Clinical Trial of TQ05105 Tablets Combined With TQB3909 Tablets in the Treatment of Myelofibrosis (MF) (clinicaltrials.gov)
    P1/2, N=21, Terminated, Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | N=93 --> 21 | Trial completion date: May 2027 --> Dec 2025 | Recruiting --> Terminated | Trial primary completion date: Jun 2026 --> Dec 2025; Per sponsor request. Premature closure was not prompted by any safety or efficacy concerns.
    Enrollment change • Trial completion date • Trial termination • Trial primary completion date
    |
    Anxu (rovadicitinib) • TQB3909
    3ms
    A Clinical Trial of Mass Balance of [14C] TQ05105 in Healthy Chinese Subjects (clinicaltrials.gov)
    P1, N=6, Completed, Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
    New P1 trial
    |
    Anxu (rovadicitinib)
    3ms
    TQ05105-Ⅱ-01: A Clinical Trial of TQ05105 Tablets in the Treatment of Moderate and High Risk Myelofibrosis (clinicaltrials.gov)
    P2, N=107, Active, not recruiting, Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Recruiting --> Active, not recruiting | Trial completion date: Sep 2023 --> Feb 2026
    Enrollment closed • Trial completion date
    |
    JAK2 (Janus kinase 2)
    |
    hydroxyurea • Anxu (rovadicitinib)
    3ms
    A Study to Evaluate Drug-Drug Interaction of TQ05105 Tablets (clinicaltrials.gov)
    P1, N=40, Completed, Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Not yet recruiting --> Completed
    Trial completion
    |
    itraconazole • Anxu (rovadicitinib) • rifampicin
    3ms
    A Study of TQ05105 Tablets in Subjects With Glucocorticoid-Refractory Acute Graft-Versus-Host Disease (aGVHD) (clinicaltrials.gov)
    P1/2, N=13, Completed, Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Active, not recruiting --> Completed
    Trial completion
    |
    Anxu (rovadicitinib)
    3ms
    A Study of TQ05105 in Patients With Chronic Graft Versus Host Disease (clinicaltrials.gov)
    P1/2, N=45, Active, not recruiting, Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Trial completion date: Dec 2024 --> Dec 2026
    Trial completion date
    |
    Anxu (rovadicitinib)
    6ms
    TQ05105 Tablet for Myelofibrosis Treatment in Ruxolitinib-Resistant or Intolerant Patients (clinicaltrials.gov)
    P1, N=9, Terminated, Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Trial completion date: Dec 2024 --> Aug 2025 | Active, not recruiting --> Terminated | Trial primary completion date: Dec 2024 --> Aug 2025; This study was closed due to business reasons. Closure was not prompted by any safety or efficacy concerns.
    Trial completion date • Trial termination • Trial primary completion date
    |
    Jakafi (ruxolitinib) • Anxu (rovadicitinib)
    6ms
    To Evaluate the Pharmacokinetics and Safety of TQ05105 Tablet in Renal Impairment Subjects (clinicaltrials.gov)
    P1, N=32, Completed, Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Not yet recruiting --> Completed | Trial primary completion date: Jul 2025 --> Mar 2025
    Trial completion • Trial primary completion date
    |
    Anxu (rovadicitinib)
    1year
    A Clinical Trial of TQ05105 Tablets in the Treatment of Chronic Graft-versus-host Disease (clinicaltrials.gov)
    P2, N=52, Recruiting, Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | N=40 --> 52
    Enrollment change
    |
    Anxu (rovadicitinib)
    over1year
    TQ05105-III-01: Evaluation of Rovadicitinib Compared to the Protocol Selected by Researchers in Third Line and Subsequent Studies of Moderate to Severe Chronic Graft-versus-host Disease (clinicaltrials.gov)
    P3, N=182, Recruiting, Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    Rituxan (rituximab) • imatinib • methotrexate • Anxu (rovadicitinib)
    over1year
    Evaluation of Rovadicitinib Compared to the Protocol Selected by Researchers in Third Line and Subsequent Studies of Moderate to Severe Chronic Graft-versus-host Disease (clinicaltrials.gov)
    P3, N=182, Not yet recruiting, Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
    New P3 trial
    |
    Rituxan (rituximab) • imatinib • methotrexate • Anxu (rovadicitinib)
    over1year
    To Evaluate the Pharmacokinetics and Safety of TQ05105 Tablet in Renal Impairment Subjects (clinicaltrials.gov)
    P1, N=32, Not yet recruiting, Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
    New P1 trial
    |
    Anxu (rovadicitinib)