Imjudo (tremelimumab-actl)

Prior radiotherapy improves PFS in patients treated with tremelimumab-durvalumab for advanced HCC. The abscopal effect and up-regulation of immune mechanisms may contribute to improved outcomes.

P3, N=111, Active, not recruiting, AstraZeneca | Trial primary completion date: Sep 2025 --> Dec 2025

Immune checkpoint inhibitors (tremelimumab and durvalumab) in combination with small- molecule agents (lenvatinib and cabozantinib) enhance T-cell activation and improve progression-free survival in HCC...HCC ME has distinct immune subtypes exhibiting different responses to treatments, which complicates biomarker selection and treatment timing. Personalized therapy based on ME is the future path in HCC management.

P3, N=730, Active, not recruiting, AstraZeneca | Trial completion date: Mar 2026 --> Oct 2026

Seven tremelimumab-related serious adverse events (grade 2-3) occurred in 5 patients. While the primary PFS6 endpoint was not met, there were two durable objective responses in rare cancers and a favourable change in disease trajectory for an additional five patients based on TTP ratio 1.3.

Clinical evidence indicates that programmed death-1/cytotoxic T-lymphocyte-associated protein 4 (PD-1/CTLA-4) dual immune checkpoint blockade strategies (e.g., durvalumab plus tremelimumab, nivolumab plus ipilimumab) exhibit differential therapeutic effects: durable treatment responses have been observed in recurrent/platinum-resistant advanced OC, while neoadjuvant applications have significantly improved complete resection rates. In conclusion, despite existing challenges, dual-target immunotherapy has demonstrated clinically meaningful benefits, offering new therapeutic options for advanced and recurrent OC patients and heralding a new era of combination immunotherapy in OC treatment. Future large-scale clinical studies are warranted to further validate efficacy and establish individualized precision treatment strategies.

P2, N=0, Withdrawn, Weill Medical College of Cornell University | N=10 --> 0 | Not yet recruiting --> Withdrawn

These findings suggest that CD8-Temra cells may serve as potential biomarkers and therapeutic targets for immunotherapy efficacy in pancreatic ductal adenocarcinoma, pending validation in larger cohorts. We hypothesize that local tumor ablation may enhance tumor immunogenicity and systemic anti-tumor responses, supporting their integration into future treatment strategies. Future studies with larger cohorts are needed to validate these findings and optimize treatment protocols for wider clinical applicability.

P2, N=140, Recruiting, Canadian Cancer Trials Group | Not yet recruiting --> Recruiting

P2, N=571, Active, not recruiting, MedImmune LLC | Trial completion date: Apr 2025 --> Jun 2026

P1/2, N=340, Completed, AstraZeneca | Active, not recruiting --> Completed

P2, N=14, Completed, John L. Villano, MD, PhD | Active, not recruiting --> Completed