Uterine Cancer

P2, N=30, Recruiting, Dana-Farber Cancer Institute | Not yet recruiting --> Recruiting

P1, N=48, Not yet recruiting, Kumquat Biosciences Inc.

P3, N=10, Completed, UMC Utrecht | Not yet recruiting --> Completed

Moreover, in a syngeneic mouse tumor model of cervical cancer, treatment with pch-miR319a effectively inhibits tumor growth and downregulates the expressions of ITGA3 and the proliferation marker Ki-67. Our study highlights the potential of pch-miR319a from P. chinensis as a novel therapeutic agent for cervical cancer by targeting ITGA3 and provides new insights into the cross-kingdom regulatory mechanisms of plant miRNAs in human diseases.

P3, N=480, Recruiting, BioNTech SE

P=N/A, N=1000, Recruiting, University of British Columbia | Not yet recruiting --> Recruiting

Elevated preoperative CRP levels are significantly associated with uterine sarcoma and may enhance oncologic risk stratification prior to surgery. Integration of CRP into multimodal preoperative assessment algorithms could improve surgical planning and reduce the risk of inadvertent tumour dissemination. Prospective multicentre studies are required to validate its diagnostic performance and define clinically relevant cut-off values.

EPA exhibits potent anti-tumor activity against USC cells and enhances the efficacy of carboplatin. These data indicate that EPA has potential as a low-toxicity, multi-target adjuvant treatment for USC, necessitating additional pre-clinical and clinical investigation.

P4, N=96, Completed, University of British Columbia | Active, not recruiting --> Completed | N=250 --> 96

Postoperatively, she was treated with an Ewing sarcoma‑based chemotherapy protocol (vincristine, doxorubicin, cyclophosphamide/ifosfamide and etoposide (VDC/IE)), but unfortunately, she died 10 months after surgery. While on one hand, among adolescents, fertility preservation poses an additional ethical and therapeutic challenge, on the other hand, rapid, individualised decision‑making is also required to prevent clinical deterioration. This case highlights the diagnostic and therapeutic dilemmas faced, the need to consider PNET in the differential diagnosis of aggressive uterine masses even in adolescents, the important role of ancillary testing like IHC and molecular studies for a definitive diagnosis and the difficulties in balancing life‑saving surgery and fertility preservation when disease is advanced.

FOLH1 may be involved in tumor progression by regulating amino acid metabolic pathways and the immune microenvironment. It is a promising pan-cancer prognostic marker and synergistic target for immunotherapy.

Despite aggressive histological features, the absence of myometrial invasion supports definitive surgery followed by intensive long-term surveillance. This report underscores the necessity of a high index of suspicion for malignancy in recurrent polypoid masses within the reproductive age group and addresses critical gaps regarding fertility preservation and age-specific management protocols.