^
    10d
    NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation. (PubMed, Adv Sci (Weinh))
    Drug screening identified the HIV protease inhibitor nelfinavir as a specific disruptor of the NIBAN2-FLII complex...Collectively, this study, for the first time, reveals that NIBAN2 maintains GSCs stemness by activating FLII-RREB1 axis and TLR3 signaling, thereby establishing a feed-forward signaling-transcription-metabolism axis. This finding provides a novel strategy and potential targets for precise therapeutic intervention against glioma stemness.
    Journal • IO biomarker
    |
    LDHA (Lactate dehydrogenase A) • CD44 (CD44 Molecule) • SOX2 • TLR3 (Toll Like Receptor 3) • RREB1 (Ras Responsive Element Binding Protein 1)
    |
    Viracept (nelfinavir)
    10d
    NELCER: Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Cervix (clinicaltrials.gov)
    P3, N=348, Completed, Tata Memorial Hospital | Active, not recruiting --> Completed
    Trial completion
    |
    cisplatin • Viracept (nelfinavir) • ondansetron intravenous
    15d
    Potency-enhancing mutations in E3-19K and i-leader increase the cytolytic activity of the PH20/SPAM1-armed oncolytic adenovirus Ad5Δ24RGD. (PubMed, Mol Ther Oncol)
    In some cell lines, the fiber modification F5RGD10(2C) or verapamil treatment further improves actual spread efficiency. Nelfinavir inhibits spread and plaque formation of oncolytic adenoviruses with the 19KSS-iLQ125Ter modifications, irrespective of adenovirus death protein (ADP) expression...We identified an insertion site downstream of the L3-23K region that supports relatively high hPH20 activity while preserving the enhanced oncolytic potency of the virus. Combining 19KSS-iLQ125Ter with hPH20 expression may potentially improve therapeutic benefit in glioma.
    Journal
    |
    SPAM1 (Sperm Adhesion Molecule 1)
    |
    Viracept (nelfinavir)
    29d
    NELCER: Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Cervix (clinicaltrials.gov)
    P3, N=348, Active, not recruiting, Tata Memorial Hospital | Trial completion date: Jan 2026 --> Apr 2026
    Trial completion date
    |
    cisplatin • Viracept (nelfinavir) • ondansetron intravenous
    2ms
    NELCER: Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Cervix (clinicaltrials.gov)
    P3, N=348, Active, not recruiting, Tata Memorial Hospital | Trial completion date: Sep 2025 --> Jan 2026
    Trial completion date
    |
    cisplatin • Viracept (nelfinavir) • ondansetron intravenous
    2ms
    Darunavir analog precursors target mitochondrial metabolism in multiple myeloma and CLL. (PubMed, Cancer Cell Int)
    BupM-NH2, and particularly BnpM-NH2, showed enhanced cytotoxicity against MM, CLL, and NDMM cells compared to PBMCs by inducing apoptosis through autophagy and mitochondrial respiration inhibition. While the cytotoxic effect in RRMM is less pronounced and nonsignificant, BupM-NH2 and BnpM-NH2 induces stress in respiratory chain and mitochondria, which may re-sensitize resistant tumor cells to treatments. Therefore these compounds may hold promise as novel therapeutic agents for MM and CLL treatment.
    Journal
    |
    ANXA5 (Annexin A5)
    |
    Venclexta (venetoclax) • bortezomib • Viracept (nelfinavir)
    2ms
    Autophagy Maintenance (AUTOMAIN) (clinicaltrials.gov)
    P2, N=38, Recruiting, Medical University of South Carolina | Not yet recruiting --> Recruiting | N=20 --> 38 | Trial completion date: Dec 2027 --> Jun 2029 | Trial primary completion date: Dec 2026 --> Jun 2028
    Enrollment open • Enrollment change • Trial completion date • Trial primary completion date
    |
    Avastin (bevacizumab) • hydroxychloroquine • Viracept (nelfinavir)
    3ms
    Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore Iron Delivery to the Bone Marrow (clinicaltrials.gov)
    P1/2, N=10, Recruiting, University of California, Irvine
    New P1/2 trial
    |
    Viracept (nelfinavir)
    5ms
    Nelfinavir, Cisplatin, and External Beam Radiation Therapy for the Treatment of Locally Advanced Vulvar Cancer That Cannot Be Removed by Surgery (clinicaltrials.gov)
    P1, N=25, Recruiting, M.D. Anderson Cancer Center | N=18 --> 25
    Enrollment change
    |
    cisplatin • Viracept (nelfinavir)
    5ms
    COAST Therapy in Advanced Solid Tumors and Prostate Cancer (clinicaltrials.gov)
    P1/2, N=76, Recruiting, Medical University of South Carolina | Trial completion date: Oct 2026 --> May 2027 | Trial primary completion date: Oct 2025 --> May 2026
    Trial completion date • Trial primary completion date
    |
    dasatinib • sirolimus • metformin • hydroxychloroquine • Viracept (nelfinavir)
    5ms
    Autophagy Maintenance (AUTOMAIN) (clinicaltrials.gov)
    P2, N=20, Not yet recruiting, Medical University of South Carolina | Initiation date: Sep 2025 --> Jan 2026
    Trial initiation date
    |
    Avastin (bevacizumab) • hydroxychloroquine • Viracept (nelfinavir)
    5ms
    Nelfinavir triggers ferroptosis by inducing ER stress mediated downregulation of GPX4/GSH system, upregulation of NRF2/HO-1 axis, and mitochondrial impairment in hepatocellular carcinoma cells. (PubMed, Cell Death Discov)
    In a mouse model of HCC xenografts, nelfinavir treatment significantly suppressed tumor growth, and this effect was more pronounced when nelfinavir and sorafenib were administered together. Collectively, we demonstrate that nelfinavir can induce ferroptosis in an ER stress dependent manner, thereby identifying a new inducer of ferroptosis that can potentially be repurposed to treat HCC.
    Journal
    |
    HMOX1 (Heme Oxygenase 1) • GPX4 (Glutathione Peroxidase 4)
    |
    sorafenib • Viracept (nelfinavir)