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    DRUG CLASS:

    Viral entry inhibitor

    Related drugs:
    2d
    Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1 (clinicaltrials.gov)
    P1, N=48, Recruiting, National Institute of Allergy and Infectious Diseases (NIAID) | Not yet recruiting --> Recruiting
    Enrollment open
    7d
    A Study to Evaluate Tobevibart+Elebsiran Versus Bulevirtide in Chronic HDV Infection (clinicaltrials.gov)
    P2, N=100, Active, not recruiting, Vir Biotechnology, Inc. | Recruiting --> Active, not recruiting | Trial completion date: Apr 2031 --> Jul 2030
    Enrollment closed • Trial completion date
    24d
    Comparative Investigation of the Effects of Adenosine Triphosphate, Melatonin, and Thiamine Pyrophosphate on Amiodarone-Induced Neuropathy and Neuropathic Pain in Male Rats. (PubMed, Biomedicines)
    TPP exhibited superior neuroprotective efficacy compared with ATP and melatonin, highlighting its potential as a candidate therapeutic agent for amiodarone-related neuropathy. Further clinical research is warranted to support translational application of these findings.
    Preclinical • Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL1B (Interleukin 1, beta) • CAT (Catalase)
    1m
    PARACA: Prophylactic Anti-aRrhythmic Therapy With Amiodarone in Critically Ill Patients Admitted for an Out-of-hospital Cardiac Arrest With Initial Shockable Rhythm (clinicaltrials.gov)
    P3, N=674, Recruiting, Versailles Hospital | Not yet recruiting --> Recruiting | Initiation date: Jun 2025 --> Nov 2025
    Enrollment open • Trial initiation date
    1m
    VISTA: HIV-1 Virologic Suppression With TMB-365 and TMB-380 Antibodies Study (clinicaltrials.gov)
    P2, N=75, Recruiting, TaiMed Biologics Inc. | Not yet recruiting --> Recruiting
    Enrollment open
    2ms
    A Pharmaco-surgical Approach to Reduce Postoperative Atrial Fibrillation After Cardiac Surgery (clinicaltrials.gov)
    P=N/A, N=242, Completed, Massachusetts General Hospital | Active, not recruiting --> Completed | Trial completion date: Dec 2024 --> Mar 2025
    Trial completion • Trial completion date
    2ms
    PATRONUS: Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery (clinicaltrials.gov)
    P4, N=242, Not yet recruiting, Massachusetts General Hospital | Trial completion date: Dec 2025 --> Dec 2027 | Trial primary completion date: Jul 2025 --> Jan 2027
    Trial completion date • Trial primary completion date
    2ms
    A Platform Study to Evaluate Investigational Therapies in Chronic Hepatitis B Infection (clinicaltrials.gov)
    P1/2, N=33, Completed, Vir Biotechnology, Inc. | Active, not recruiting --> Completed | N=150 --> 33 | Trial completion date: Mar 2027 --> Aug 2025
    Trial completion • Enrollment change • Trial completion date
    2ms
    Shortening Duration of Antiarrhythmic Medication for SVT in Infants (clinicaltrials.gov)
    P=N/A, N=107, Completed, Tampere University Hospital | Recruiting --> Completed | N=70 --> 107
    Trial completion • Enrollment change
    2ms
    RESTART: Reducing Systemic Inflammation in People on Antiretroviral Therapy (clinicaltrials.gov)
    P2, N=150, Recruiting, Centre hospitalier de l'Université de Montréal (CHUM) | Not yet recruiting --> Recruiting
    Enrollment open
    2ms
    A Study to Evaluate Tobevibart + Elebsiran in Chronic HDV Infection (clinicaltrials.gov)
    P3, N=124, Active, not recruiting, Vir Biotechnology, Inc. | Recruiting --> Active, not recruiting
    Enrollment closed
    2ms
    A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection (clinicaltrials.gov)
    P1, N=40, Not yet recruiting, National Institute of Allergy and Infectious Diseases (NIAID) | Initiation date: Oct 2025 --> Feb 2026
    Trial initiation date