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    BIOMARKER:

    WDR5 overexpression

    i
    Other names: WD Repeat Domain 5, Cilia And Flagella Associated Protein 89, WD Repeat-Containing Protein 5, BMP2-Induced 3-Kb Gene Protein, CFAP89, SWD3, SWD3, Set1c WD40 Repeat Protein, Homolog (S. Cerevisiae), SWD3, Set1c WD40 Repeat Protein, Homolog, BIG-3, WDR5, BIG3
    Entrez ID:
    11091
    12ms
    Effect of subcutaneous adipose tissue-associated CSRP2 on the progression of prostate cancer via the WDR5/USP44 pathway. (PubMed, Am J Cancer Res)
    Overexpression of WDR5 reversed the growth inhibition of CSRP2 overexpression on prostate cancer cells. Altogether, our data indicate that CSRP2 suppresses prostate cancer cell proliferation via a CSRP2/WDR5/USP44 dependent pathway to control prostate cancer progression, suggesting a potential mechanism for prostate cancer treatment.
    Journal
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    WDR5 (WD Repeat Domain 5) • USP44 (Ubiquitin Specific Peptidase 44)
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    WDR5 overexpression
    almost3years
    USP44 accelerates the growth of T-cell acute lymphoblastic leukemia through interacting with WDR5 and repressing its ubiquitination. (PubMed, Int J Med Sci)
    In conclusion, this study indicated that USP44 enhanced the growth of T-ALL through interacting with WDR5 and repressing its ubiquitination. This study highlights the potential use of USP44 as a therapeutic target of T-ALL.
    Journal • PARP Biomarker
    |
    CASP3 (Caspase 3) • PCNA (Proliferating cell nuclear antigen) • WDR5 (WD Repeat Domain 5) • USP44 (Ubiquitin Specific Peptidase 44)
    |
    WDR5 overexpression
    3years
    WDR5 is a prognostic biomarker of brain metastasis from non-small cell lung cancer. (PubMed, Front Oncol)
    High expression of WDR5 can predict the poor prognosis of BM, and WDR5 is an independent prognostic biomarker of BM from NSCLC. Patients with WDR5 overexpression are more high-risk to suffer BM-related death and should receive more intense post-operational supervision.
    Journal
    |
    WDR5 (WD Repeat Domain 5)
    |
    WDR5 overexpression
    3years
    Circ_0072995 drives cervical cancer development by regulating the miR-29a/WDR5 axis. (PubMed, J Obstet Gynaecol)
    For the first time, our study revealed the key role of WDR5 in cervical cancer progression regulated by circ_0072995. We first reported the promoting effects of circ_0072995 in cervical cancer development by inducing miR-29a mediated WDR5 expression and also revealed the therapeutic potential of circ_0072995, miR-29a, and WDR5 in cervical cancer.
    Journal
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    WDR5 (WD Repeat Domain 5) • MIR29A (MicroRNA 29a)
    |
    WDR5 overexpression