^
    2d
    CHINANEO: A Study to Learn How Well a Combination of Darolutamide and Androgen Deprivation Therapy (ADT) Works as a Treatment Before Surgery for Men Who Have High-risk Localized Prostate Cancer. (clinicaltrials.gov)
    P2, N=250, Not yet recruiting, Bayer
    New P2 trial
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    Nubeqa (darolutamide) • goserelin acetate
    9d
    Penile metastasis from prostate cancer with CDK12 mutation: A case report and literature review. (PubMed, Oncol Lett)
    The patient was started on androgen deprivation therapy with goserelin (10.8 mg every 3 months) and bicalutamide (50 mg once daily), and stable disease was achieved for 66 months...Bicalutamide was replaced by enzalutamide (160 mg once daily) in the treatment regimen. Subsequently, based on the identification of CDK12 mutations by genetic testing, treatment with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib (300 mg twice daily) was initiated. To date, the patient has remained clinically stable with low PSA levels. This case highlights the potential utility of molecular profiling and combined PARP inhibition and androgen receptor-targeting therapy in CDK12-mutated metastatic castration-resistant PCa with rare penile metastasis.
    Journal • PARP Biomarker
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    CDK12 (Cyclin dependent kinase 12)
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    CDK12 mutation
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    Lynparza (olaparib) • Xtandi (enzalutamide) • bicalutamide • goserelin acetate
    9d
    CLEE011O12001: A trial to learn more about the effects of ribociclib taken with endocrine therapy in patients with early breast cancer. (2022-503001-38-01)
    P2/3, N=172, Active, not recruiting, Novartis Pharma AG | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
    |
    ER positive • PGR positive
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    Kisqali (ribociclib) • letrozole • anastrozole • exemestane • goserelin acetate • leuprolide acetate for depot suspension
    10d
    A Study to Assess the Bioequivalence of Follitropin Alfa Solution in Pen and Follitropin Alfa Powder in Vial in Healthy Downregulated Male Participants (clinicaltrials.gov)
    P1, N=55, Completed, EMD Serono Research & Development Institute, Inc. | Recruiting --> Completed
    Trial completion
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    goserelin acetate
    17d
    UC-BCG-2409/BIG 2402: Evaluating a Personalized Treatment Strategy for Young Women with Early Breast Cancer (2024-519655-28-00)
    P2/3, N=2270, Not yet recruiting, Unicancer
    New P2/3 trial
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
    |
    HER-2 positive • HR positive • HER-2 negative • HER-2 expression • ER negative
    |
    Prosigna™ Breast Cancer Prognostic Gene Signature Assay
    |
    paclitaxel • docetaxel • tamoxifen • doxorubicin hydrochloride • cyclophosphamide • letrozole • epirubicin • anastrozole • exemestane • triptorelin • goserelin acetate • leuprolide acetate for depot suspension
    17d
    UC-BCG-2501: NoLEEta - Phase III non-inferiority trial of chemotherapy de-escalation in hormone receptorpositive, Her2-negative, intermediate-risk early breast cancer treated with Ribociclib (LEE-011) innthe adjuvant setting (2025-520979-13-00)
    P2/3, N=3306, Recruiting, Unicancer
    New P2/3 trial • Head-to-Head
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
    |
    ER positive • HER-2 negative • HER-2 negative + ER positive
    |
    paclitaxel • docetaxel • doxorubicin hydrochloride • albumin-bound paclitaxel • cyclophosphamide • Kisqali (ribociclib) • letrozole • epirubicin • anastrozole • exemestane • triptorelin • goserelin acetate • leuprolide acetate for depot suspension
    17d
    Assessing the Efficacy and Safety of Anti-HER2 Therapy in Nigerian Women With HER2+ Breast Cancer Before and After Surgery (clinicaltrials.gov)
    P2, N=74, Recruiting, University of Chicago | Not yet recruiting --> Recruiting
    Enrollment open
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    HER-2 positive
    |
    docetaxel • Perjeta (pertuzumab) • Kadcyla (ado-trastuzumab emtansine) • letrozole • goserelin acetate • Soltamox (tamoxifen citrate)
    17d
    GEICAM/2023-09: Impact of EXercise on quality of life of early breast cancer patients on treatment with adjuvant Aromatase Inhibitors with or without CDK4/6 inhibitors. "The EX-AI study" (2025-522848-40-00)
    P4, N=74, Not yet recruiting, Fundacion Grupo Espanol De Investigacion En Cancer De Mama
    New P4 trial • HEOR
    |
    HER-2 (Human epidermal growth factor receptor 2) • CDK4 (Cyclin-dependent kinase 4)
    |
    HER-2 negative
    |
    Verzenio (abemaciclib) • Kisqali (ribociclib) • letrozole • anastrozole • goserelin acetate
    24d
    Study of Neoadjuvant Endocrine Therapy in HR Positive and HER2 Negative Premenopausal Breast Cancer Patients (clinicaltrials.gov)
    P2/3, N=119, Completed, Tianjin Medical University Cancer Institute and Hospital | Recruiting --> Completed | Trial completion date: Sep 2026 --> Sep 2025
    Trial completion • Trial completion date
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
    |
    ER positive • HER-2 negative • HER-2 expression
    |
    cyclophosphamide • epirubicin • exemestane • AiRuiKang (dalpiciclib) • goserelin acetate
    29d
    CASPAR: A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy (clinicaltrials.gov)
    P3, N=61, Active, not recruiting, Alliance for Clinical Trials in Oncology | Trial primary completion date: Mar 2026 --> Mar 2027
    Trial primary completion date
    |
    Xtandi (enzalutamide) • Rubraca (rucaparib) • goserelin acetate • Firmagon (degarelix) • leuprolide acetate for depot suspension
    29d
    Safety and Efficacy Evaluation of LC-K76 in Patients With Metastatic Hormone-Sensitive Prostate Cancer (clinicaltrials.gov)
    P1, N=40, Not yet recruiting, Shanghai Changzheng Hospital
    New P1 trial
    |
    Xtandi (enzalutamide) • triptorelin • goserelin acetate
    29d
    Safety and Preliminary Efficacy Evaluation of LC-K76 Plus Anti-PD-1 Therapy in Patients With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (clinicaltrials.gov)
    P1, N=10, Not yet recruiting, Shanghai Changzheng Hospital
    New P1 trial
    |
    Tevimbra (tislelizumab-jsgr) • triptorelin • goserelin acetate