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    This assay detects genetic variants in the dihydropyrimidine dehydrogenase (DPYD) gene. The list of variants included in the assay is shown below. The DPYD gene encodes the dihydropyrimidine dehydrogenase (DPD) enzyme. The DPD enzyme metabolizes fluoropyrimidine drugs including 5 fluorouracil (5-FU) and capecitabine; these drugs are frequently used as chemotherapeutic agents for colorectal cancer and other solid tumors.
    Cancer:
    Colorectal Cancer, Solid Tumor
    Gene:
    DPYD (Dihydropyrimidine Dehydrogenase)
    Drug:
    5-fluorouracil, capecitabine
    Method:
    RT-PCR