TEST:

Lung Cancer Mutation Panel

Besides BAY-293, BH1406 cells proved to be sensitive to the SOS1 inhibitors MRTX0902 and BI-3406...Additionally, the PI3K inhibitor dactolisib, the GSK-3 inhibitor BI-5521 as well as the bromodomain protein-directed PROTAC ARV-771 inhibited the growth of BH1406 cells significantly and showed synergistic interaction with BAY-293...BH1406 cells represent a novel cellular model suitable for the molecular characterization of SOS1 druggability. Such rare oncogenic driver genes are not included in standard NGS panels and need to be detected by expanded assays like WES.

At this time the patient was started on carboplatin, paclitaxel, and pembrolizumab. Despite incomplete staining results this case demonstrates possible concurrent PEComa and squamous cell lung cancer.

This patient's presentation with diffuse inflammatory pattern and lack of nodules is unique with few similar cases reported, particularly in female non-smokers. It is important to continue recognizing and documenting cases of uncommon presentations of adenocarcinoma to better understand its course and trigger prompt diagnosis and treatment.