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    TEST:
    Omics Core

    Company:
    NantHealth
    Type:
    FDA Cleared (510k)
    Details
    Evidence

    News

    25d
    TIMP1 and PKM drive immunosuppression and metabolic remodeling to promote colorectal cancer progression through integrated multi-omics analysis. (PubMed, Int J Biol Macromol)
    Functionally, treatment with a PKM inhibitor significantly suppressed lactate production. This study reveals that TIMP1 promotes immunosuppression and PKM-LDHA drives metabolic reprogramming in CRC.
    Journal • Tumor mutational burden • IO biomarker
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    TMB (Tumor Mutational Burden) • LDHA (Lactate dehydrogenase A) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • HDAC2 (Histone deacetylase 2) • E2F1 (E2F transcription factor 1) • PKM (Pyruvate Kinase M1/2)
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    TMB-L
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    Omics Core
    almost2years
    Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center. (PubMed, Sci Data)
    The GHTO has performed deep molecular profiling (genomic, transcriptomic, epigenomic, proteomic, and metabolomic) from large number of brain (n = 2,117), CSF (n = 2,012) and blood/plasma (n = 8,265) samples with the goal of identifying novel risk and protective variants, identify novel molecular biomarkers and causal and druggable targets. Overall, the resources available at GHTO support the increase of our understanding of Alzheimer Disease.
    Journal
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    Omics Core