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BIOMARKER:

ALK rearrangement + BRCA2 F2801fs

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Entrez ID:

Related biomarkers:

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BRCA2 mutation (200)

ALK rearrangement (43)

ALK mutation (20)

BRCA wild-type (19)

ALK wild-type (18)

STRN-ALK rearrangement (10)

ALK translocation (9)

EGFR wild-type + ALK wild-type (7)

EML4-ALK rearrangement (5)

ALK G1202del (4)

ALK rearrangement + TP53 mutation (4)

BRCA1 mutation + BRCA2 mutation (4)

TYRO3 mutation + ALK mutation (3)

BRCA2 A902fs*2 (3)

ALK C1156Y + ALK I1171T (2)

ALK C1156Y + ALK L1198F (2)

ALK F1174L + ALK G1202R (2)

DCTN1-ALK rearrangement + ALK-CLIP4 rearrangement (2)

BRCA2 mutation + CHEK2 mutation (2)

BRCA2 mutation + TP53 mutation (2)

BRCA2 rearrangement (2)

ALK C1156Y + ALK G1202R (1)

ALK G1202R + ALK F1174L + ALK T1151M (1)

ALK L1152R + EGFR mutation (1)

ALK L1196M + ALK C1156Y (1)

ALK L1196M + ALK G1202R (1)

ALK L1196M + ALK L1198F (1)

ALK L1198F + ALK G1202R (1)

ALK TKD mutation (1)

ALK rearrangement + ALK L1196M + TP53 mutation (1)

ALK rearrangement + ALK R1275Q + TP53 mutation (1)

ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)

ALK rearrangement + EGFR D761N + KRAS V14I (1)

ALK rearrangement + HER-2 mutation (1)

ALK rearrangement + KRAS mutation (1)

ALK rearrangement + PIK3CA mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

ALK rearrangement + TP53 wild-type (1)

EGFR L858R + ALK R1275Q (1)

EGFR L858R + ALK rearrangement (1)

EGFR exon 19 deletion + ALK mutation (1)

EGFR mutation + ALK mutation (1)

EGFR wild-type + ALK wild-type + ROS1 wild-type (1)

EGFR wild-type + ALK wild-type + STK11 mutation (1)

EML4-ALK I1171N + EML4-ALK L1196M (1)

EML4-ALK I1171N + EML4-ALK L1196M + EML4-ALK G1202R (1)

LMO7-ALK rearrangement (1)

PLEKHH2-ALK rearrangement (1)

RMST-ALK rearrangement (1)

TP53 G245S + ALK rearrangement (1)

APC mutation + BRCA2 mutation (1)

BRCA2 1153insT (1)

BRCA2 5396insC (1)

BRCA2 I2315T (1)

BRCA2 L557* (1)

BRCA2 N255fs + D252fs (1)

BRCA2 Y1655* + TP53 mutation (1)

BRCA2 biallelic inactivation (1)

BRCA2 mutation + ATM mutation (1)

BRCA2 mutation + CDK12 mutation (1)

BRCA2 mutation + SPOP mutation (1)

BRCA2 mutation + TP53 D816Y (1)

CHEK2 mutation + ATM mutation + BRCA2 mutation (1)

EGFR exon 19 deletion + BRCA2 mutation (1)

ALK mutation + TP53 mutation (0)

BRCA2 E260fs (0)

BRCA2 N255_R259delinsIK (0)

BRCA2 N255fs (0)

BRCA2 N255fs + BRCA2 N255_R259delinsIK + BRCA2 E260fs (0)

BRCA2 mutation (200)

ALK rearrangement (43)

ALK mutation (20)

BRCA wild-type (19)

ALK wild-type (18)

STRN-ALK rearrangement (10)

ALK translocation (9)

EGFR wild-type + ALK wild-type (7)

EML4-ALK rearrangement (5)

ALK G1202del (4)

ALK rearrangement + TP53 mutation (4)

BRCA1 mutation + BRCA2 mutation (4)

TYRO3 mutation + ALK mutation (3)

BRCA2 A902fs*2 (3)

ALK C1156Y + ALK I1171T (2)

ALK C1156Y + ALK L1198F (2)

ALK F1174L + ALK G1202R (2)

DCTN1-ALK rearrangement + ALK-CLIP4 rearrangement (2)

BRCA2 mutation + CHEK2 mutation (2)

BRCA2 mutation + TP53 mutation (2)

BRCA2 rearrangement (2)

ALK C1156Y + ALK G1202R (1)

ALK G1202R + ALK F1174L + ALK T1151M (1)

ALK L1152R + EGFR mutation (1)

ALK L1196M + ALK C1156Y (1)

ALK L1196M + ALK G1202R (1)

ALK L1196M + ALK L1198F (1)

ALK L1198F + ALK G1202R (1)

ALK TKD mutation (1)

ALK rearrangement + ALK L1196M + TP53 mutation (1)

ALK rearrangement + ALK R1275Q + TP53 mutation (1)

ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)

ALK rearrangement + EGFR D761N + KRAS V14I (1)

ALK rearrangement + HER-2 mutation (1)

ALK rearrangement + KRAS mutation (1)

ALK rearrangement + PIK3CA mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

ALK rearrangement + TP53 wild-type (1)

EGFR L858R + ALK R1275Q (1)

EGFR L858R + ALK rearrangement (1)

EGFR exon 19 deletion + ALK mutation (1)

EGFR mutation + ALK mutation (1)

EGFR wild-type + ALK wild-type + ROS1 wild-type (1)

EGFR wild-type + ALK wild-type + STK11 mutation (1)

EML4-ALK I1171N + EML4-ALK L1196M (1)

EML4-ALK I1171N + EML4-ALK L1196M + EML4-ALK G1202R (1)

LMO7-ALK rearrangement (1)

PLEKHH2-ALK rearrangement (1)

RMST-ALK rearrangement (1)

TP53 G245S + ALK rearrangement (1)

APC mutation + BRCA2 mutation (1)

BRCA2 1153insT (1)

BRCA2 5396insC (1)

BRCA2 I2315T (1)

BRCA2 L557* (1)

BRCA2 N255fs + D252fs (1)

BRCA2 Y1655* + TP53 mutation (1)

BRCA2 biallelic inactivation (1)

BRCA2 mutation + ATM mutation (1)

BRCA2 mutation + CDK12 mutation (1)

BRCA2 mutation + SPOP mutation (1)

BRCA2 mutation + TP53 D816Y (1)

CHEK2 mutation + ATM mutation + BRCA2 mutation (1)

EGFR exon 19 deletion + BRCA2 mutation (1)

ALK mutation + TP53 mutation (0)

BRCA2 E260fs (0)

BRCA2 N255_R259delinsIK (0)

BRCA2 N255fs (0)

BRCA2 N255fs + BRCA2 N255_R259delinsIK + BRCA2 E260fs (0)

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ALK rearrangement + BRCA2 F2801fs

Lung Adenocarcinoma

olaparib + lorlatinib

Sensitive: C4 – Case Studies

olaparib + lorlatinib

olaparib + lorlatinib

Sensitive: C4 – Case Studies

olaparib + lorlatinib