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BIOMARKER:
MYC overexpression + IDH1 mutation
i
Other names:
MYC, bHLHe39, c-Myc, MYCC, V-myc avian myelocytomatosis viral oncogene homolog, HEL-216, HEL-S-26, Epididymis Luminal Protein 216, Isocitrate Dehydrogenase 1 (NADP+), Epididymis Secretory Protein Li 26, IDH1, Isocitrate Dehydrogenase (NADP(+)) 1, Isocitrate Dehydrogenase 1 (NADP+), Soluble
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Entrez ID:
4609
;
3417
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
IDH1 mutation (79)
MYC rearrangement + BCL2 rearrangement (22)
MYC rearrangement + BCL6 rearrangement (9)
IDH1 R132H (9)
MYC rearrangement (7)
MYC rearrangement + BCL2 rearrangement + BCL6 rearrangement (6)
MYC mutation (5)
IDH1 R132C (5)
MYC translocation (4)
MYC translocation + BCL2 translocation (3)
IDH wild-type (3)
IDH1 R132 (3)
FLT3-ITD mutation + IDH1 mutation (2)
IDH1 R132G (2)
IDH1 wild-type + BRAF mutation (2)
IDH1 wild-type + NF1 mutation (2)
EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)
MYC translocation + BCL6 translocation (1)
MYC translocation + BCL6 translocation + BCL2 translocation (1)
DNMT3A mutation + IDH mutation (1)
EGFR L858R + IDH1 R132C (1)
EGFR mutation + IDH1 mutation (1)
EGFR mutation+ IDH1 R132H (1)
FLT3 mutation + IDH1 mutation (1)
IDH1 R132C + EGFR L861Q (1)
IDH1 R132C + IDH1 S280F (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
IDH1 R132H + PTEN C78T (1)
IDH1 R132L (1)
IDH1 R132S (1)
IDH1 R132V (1)
IDH1 mutation + TP53 mutation (1)
IDH1 rs1437410 (1)
MYC rearrangement + BCL2 rearrangement+ BCL6 rearrangement (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + NTRK fusion (0)
IDH mutation + NTRK fusion (0)
IDH1 mutation (79)
MYC rearrangement + BCL2 rearrangement (22)
MYC rearrangement + BCL6 rearrangement (9)
IDH1 R132H (9)
MYC rearrangement (7)
MYC rearrangement + BCL2 rearrangement + BCL6 rearrangement (6)
MYC mutation (5)
IDH1 R132C (5)
MYC translocation (4)
MYC translocation + BCL2 translocation (3)
IDH wild-type (3)
IDH1 R132 (3)
FLT3-ITD mutation + IDH1 mutation (2)
IDH1 R132G (2)
IDH1 wild-type + BRAF mutation (2)
IDH1 wild-type + NF1 mutation (2)
EGFR exon 19 deletion + ATM S1455fs*36 + MYC E62K (1)
MYC translocation + BCL6 translocation (1)
MYC translocation + BCL6 translocation + BCL2 translocation (1)
DNMT3A mutation + IDH mutation (1)
EGFR L858R + IDH1 R132C (1)
EGFR mutation + IDH1 mutation (1)
EGFR mutation+ IDH1 R132H (1)
FLT3 mutation + IDH1 mutation (1)
IDH1 R132C + EGFR L861Q (1)
IDH1 R132C + IDH1 S280F (1)
IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)
IDH1 R132H + PTEN C78T (1)
IDH1 R132L (1)
IDH1 R132S (1)
IDH1 R132V (1)
IDH1 mutation + TP53 mutation (1)
IDH1 rs1437410 (1)
MYC rearrangement + BCL2 rearrangement+ BCL6 rearrangement (0)
IDH mutation + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) (0)
IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)
IDH mutation + Chr del(1p) + Chr del(19q) + NTRK fusion (0)
IDH mutation + NTRK fusion (0)
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MYC overexpression + IDH1 mutation
Acute Myelogenous Leukemia
MYC overexpression + IDH1 mutation
Acute Myelogenous Leukemia
enasidenib
Resistant: C3 – Early Trials
enasidenib
Resistant
:
C3
enasidenib
Resistant: C3 – Early Trials
enasidenib
Resistant
:
C3
MYC overexpression + IDH1 mutation
Acute Myelogenous Leukemia
MYC overexpression + IDH1 mutation
Acute Myelogenous Leukemia
ivosidenib
Resistant: C3 – Early Trials
ivosidenib
Resistant
:
C3
ivosidenib
Resistant: C3 – Early Trials
ivosidenib
Resistant
:
C3
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