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DRUG CLASS:

Pyk2 inhibitor

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Pyk2 inhibitor

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KRAS wild-type	Ovarian Cancer	KRAS wild-type	Ovarian Cancer	avutometinib + defactinib Sensitive: B - Late Trials avutometinib + defactinib Sensitive : B	avutometinib + defactinib Sensitive: B - Late Trials avutometinib + defactinib Sensitive : B
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KRAS G12A	Ovarian Serous Adenocarcinoma	KRAS G12A	Ovarian Serous Adenocarcinoma	avutometinib + defactinib Sensitive: C3 – Early Trials avutometinib + defactinib Sensitive : C3	avutometinib + defactinib Sensitive: C3 – Early Trials avutometinib + defactinib Sensitive : C3
KRAS G12C	Non Small Cell Lung Cancer	KRAS G12C	Non Small Cell Lung Cancer	sotorasib + avutometinib + defactinib Sensitive: D – Preclinical sotorasib + avutometinib + defactinib Sensitive : D	sotorasib + avutometinib + defactinib Sensitive: D – Preclinical sotorasib + avutometinib + defactinib Sensitive : D