ER negative

This study revealed the expression interplay and clinical significance of KIF2A and p53 in breast cancer. The identified association between KIF2A and p53 may provide insights for future research on their roles in breast cancer.

Conversely, in ER-positive tumors, apocrine morphology was associated with increased proliferation, enhanced immune-related signaling, and greater genomic instability. In conclusion, apocrine morphology represents an ER-dependent biological state with distinct prognostic and molecular implications.

P3, N=420, Not yet recruiting, Fudan University

P3, N=1978, Recruiting, National Cancer Institute (NCI) | Not yet recruiting --> Recruiting | Initiation date: Jul 2026 --> Feb 2027

Finally, we observe that co-expression increases metastatic risk in both estrogen receptor-negative and -positive breast cancers. Collectively, these findings define a novel SOX9-SEMA7A relationship in healthy mammary tissues and illustrate how studies of normal progenitor cell phenotypes can delineate cellular mechanisms that contribute to breast tumor progression.

Multimodal imaging (e.g., Computed Tomography (CT)/Magnetic Resonance Imaging (MRI)) combined with image-guided biopsy is critical for diagnosis. Early detection enables multidisciplinary palliative strategies to optimize quality of life while addressing systemic dissemination.

Calcification and surgical modality demonstrated divergent prognostic implications for IBTR and CBTR according to molecular subtype. Although calcification is traditionally considered a high-risk feature prevalent in aggressive subtypes, its presence was associated with favorable contralateral events in ER-positive DCIS. These findings emphasize the importance of integrating molecular markers with clinical features to support more personalized approaches to DCIS management.

P2, N=24, Recruiting, Fudan University

BC survivors carrying BRCA1, BRCA2, and CHEK2 PVs and ER-negative BC survivors carrying PALB2 PVs are at two-fold or higher CBC risks. These estimates may assist clinical decision making for management of the contralateral breast.

These findings highlight the potential benefit of evaluating metastatic sites when formulating treatment strategies. Further research with larger cohorts is warranted to confirm these observations and better define their impact on personalized cancer care.

Instrumental variables were selected based on criteria of P  10. We employed bidirectional two-sample MR, primarily using inverse-variance weighted methods, supplemented by MR-Egger and other techniques, to assess causal relationships and intermediary roles.

The integration of refined anatomic staging with molecular and ER-informed risk stratification enhances prognostic precision, supports multidisciplinary communication, and enables more individualised therapeutic decision-making. Familiarity with this evolving framework is essential for improving consistency of staging across institutions and for optimising clinical outcomes through earlier and more accurate identification of dissemination and metastatic potential in endometrial cancer.