HER-2 overexpression

All patients received standard neoadjuvant chemotherapy (FLOT, XELOX, or FOLFOX) followed by curative gastrectomy with D2 lymphadenectomy...HER2 overexpression is associated with poorer pathological response to standard neoadjuvant chemotherapy in gastric adenocarcinoma. These findings highlight the potential need for molecularly tailored perioperative treatment strategies in this subgroup.

Recent advancements in cancer molecular profiling and the Food and Drug Administration's approval of trastuzumab deruxtecan for HER2-positive pan-tumor indications have highlighted the broader relevance of HER2 alterations across diverse cancers...To address this gap, a multidisciplinary panel of Chinese experts has developed a consensus providing comprehensive recommendations on diagnostic strategies, testing methodologies, and clinical applications of HER2 overexpression detection. By establishing a unified framework for HER2 overexpression assessment, this consensus aims to enhance the precision of HER2 testing, optimize patient selection for targeted therapies, and improve clinical outcomes across a wide spectrum of HER2 overexpression malignancies.

HER2 overexpression is rare in prostatic carcinomas but nearly half show HER2 expression of Score 1 or above. Cases with higher Gleason score and advanced disease stage are more likely to overexpress HER2.

P2, N=30, Sun Yat-sen Memorial Hospital of Sun Yat-sen University; Sun Yat-sen Memorial Hospital of Sun Yat-sen University

P2, N=35, Recruiting, Jiangsu Cancer Hospital; Jiangsu Cancer Hospital

These findings support the importance of routine HER2 testing in breast cancer management in resource-limited settings. Although no statistically significant associations were found, this study provides additional data on HER2 expression in the Congolese context and highlights the need for larger studies with longer study periods to better assess clinicopathological associations.

In conclusion, early recurrence serves as an important predictor of poor post-recurrence survival in young breast cancer patients aged 40 years or younger. The nomogram incorporating recurrence timing, tumor burden, and molecular subtype can predict prOS with reasonable accuracy and may guide clinical risk stratification and individualized management.

HER2 expression in urothelial carcinoma was associated with a distinct immune microenvironmental profile characterized by Treg enrichment and relatively low immune checkpoint expression, as supported by our protein-level validation. These findings provide additional biological context for the potential therapeutic benefit of combining RC48 with ICIs. Given the exploratory nature of the HER2-high definition and the limited sample size of the validation cohorts, further prospective studies are warranted to confirm these observations.

Of note, 6/7 cases with HER-2 mutations exhibited limited benefit from treatment with FOLFIRI plus cetuximab with PFS inferior to 8 months. Taken together, these results highlight the need to test HER-2 gene alterations for patients with RAS/BRAF V600 WT, MSS mCRC, who are candidates for anti-epidermal growth factor receptor therapies.

The rHER2 ECD mRNA-LNP effectively circumvents HER2-specific immune tolerance. As a potent and safe platform, it induces robust coordinated humoral and cellular immunity and significantly enhances checkpoint blockade efficacy via the enrichment of TRM cells in the TME, which underscores its promising potential for the treatment of HER2-positive cancers.

P2, N=38, Recruiting, Emory University | Not yet recruiting --> Recruiting

P1, N=60, Recruiting, Memorial Sloan Kettering Cancer Center