Finally, FHD-286 and sotorasib combination treatment results in potent anti-tumor efficacy in both G12Ci-resistant and - sensitive organoid models and in vivo patient-derived xenograft (PDX) systems. These data nominate mSWI/SNF inhibition as a combination strategy to improve KRAS inhibitor efficacy, response duration, and to mitigate emergence of resistance.

P2, N=20, Not yet recruiting, Dana-Farber Cancer Institute

P1, N=33, Recruiting, Montefiore Medical Center | Not yet recruiting --> Recruiting

Compared to each drug alone, co-treatment with SNDX-5613 (revumenib) and FHD-286 or OTX015 and FHD-286 significantly reduced the in vivo AML burden and improved survival of the immune depleted mice, without inducing significant toxicity, in the xenograft models of MITR and MI-resistant PD MLL1-r AML cells. These findings highlight novel, targeted, drug combinations that overcome MI resistance in AML cells with MLL1-r or mtNPM1.

P1, N=112, Recruiting, Eli Lilly & Co.

In AML with 3q26.2 rearrangements (r) the distal GATA2 hematopoietic enhancer becomes aberrantly relocated leading to activation of EVI1 expression. In patient-derived xenograft (PDX) models of AML with MECOM-r, compared to each drug alone, co-treatment with FHD-286 and BETi OTX015 significantly reduced AML burden and improved survival, without inducing significant toxicity. These findings highlight the FHD-286-based combinations as promising therapy of AML with chromosome 3q26.2 rearrangement and EVI1 overexpression.

P1, N=33, Not yet recruiting, Montefiore Medical Center

P1, N=340, Recruiting, Eli Lilly and Company | Trial completion date: Dec 2028 --> Oct 2027 | Trial primary completion date: Dec 2028 --> Oct 2027

P1, N=340, Recruiting, Eli Lilly and Company | Trial completion date: Oct 2027 --> Dec 2028 | Trial primary completion date: Oct 2027 --> Dec 2028

P1, N=340, Recruiting, Eli Lilly and Company | Trial completion date: May 2028 --> Oct 2027

The pharmacologic inhibition of BRG1 using two selective inhibitors, BRM014 and FHD-286, revealed marked sensitivity in Ph-like B-ALL cell lines, whereas KMT2A -R B-ALL was resistant...These results support the advancement of BRG1-directed strategies as a viable treatment approach for patients with Ph-like B-ALL, with the potential to improve outcomes in this high-risk population. Higher levels of BRG1 correlate to poor clinical outcomes in Ph-like but KMT2A -R B-ALL Inhibition of BRG1 induces cell cycle arrest in Ph-like cells in vitro and extends the survival of mice in pre-clinical in vivo studies.

P1, N=340, Recruiting, Eli Lilly and Company | N=160 --> 340 | Trial completion date: Oct 2027 --> May 2028