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DRUG:

Caprelsa (vandetanib)

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Company:

Esteve, Sanofi

Drug class:

Multi-tyrosine kinase inhibitor

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No biomarker	Thyroid Gland Medullary Carcinoma	No biomarker	Thyroid Gland Medullary Carcinoma	vandetanib Sensitive: A1 - Approval vandetanib Sensitive : A1	vandetanib Sensitive: A1 - Approval vandetanib Sensitive : A1
RET fusion	Non Small Cell Lung Cancer	RET fusion	Non Small Cell Lung Cancer	vandetanib Sensitive: A2 - Guideline vandetanib Sensitive : A2	vandetanib Sensitive: A2 - Guideline vandetanib Sensitive : A2
CCDC6-RET fusion	Non Small Cell Lung Cancer	CCDC6-RET fusion	Non Small Cell Lung Cancer	vandetanib Sensitive: C3 – Early Trials vandetanib Sensitive : C3	vandetanib Sensitive: C3 – Early Trials vandetanib Sensitive : C3
KIF5B-RET fusion	Non Small Cell Lung Cancer	KIF5B-RET fusion	Non Small Cell Lung Cancer	vandetanib Sensitive: C3 – Early Trials vandetanib Sensitive : C3	vandetanib Sensitive: C3 – Early Trials vandetanib Sensitive : C3
RET rearrangement	Non Small Cell Lung Cancer	RET rearrangement	Non Small Cell Lung Cancer	vandetanib Sensitive: C3 – Early Trials vandetanib Sensitive : C3	vandetanib Sensitive: C3 – Early Trials vandetanib Sensitive : C3
RET overexpression	Estrogen Receptor Positive Breast Cancer	RET overexpression	Estrogen Receptor Positive Breast Cancer	vandetanib Sensitive: C3 – Early Trials vandetanib Sensitive : C3	vandetanib Sensitive: C3 – Early Trials vandetanib Sensitive : C3
RET fusion	Non Small Cell Lung Cancer	RET fusion	Non Small Cell Lung Cancer	everolimus + vandetanib Sensitive: C3 – Early Trials everolimus + vandetanib Sensitive : C3	everolimus + vandetanib Sensitive: C3 – Early Trials everolimus + vandetanib Sensitive : C3
AKT2 amplification	Lung Adenocarcinoma	AKT2 amplification	Lung Adenocarcinoma	vandetanib Sensitive: C4 – Case Studies vandetanib Sensitive : C4	vandetanib Sensitive: C4 – Case Studies vandetanib Sensitive : C4
NF1 mutation	Thyroid Gland Medullary Carcinoma	NF1 mutation	Thyroid Gland Medullary Carcinoma	vandetanib Sensitive: C4 – Case Studies vandetanib Sensitive : C4	vandetanib Sensitive: C4 – Case Studies vandetanib Sensitive : C4
RET M918T + ATM L804fs4 + ATM S978fs12	Thyroid Gland Medullary Carcinoma	RET M918T + ATM L804fs4 + ATM S978fs12	Thyroid Gland Medullary Carcinoma	everolimus + vandetanib Sensitive: C4 – Case Studies everolimus + vandetanib Sensitive : C4	everolimus + vandetanib Sensitive: C4 – Case Studies everolimus + vandetanib Sensitive : C4
ATM S978fs*12	Thyroid Gland Medullary Carcinoma	ATM S978fs*12	Thyroid Gland Medullary Carcinoma	everolimus + vandetanib Sensitive: C4 – Case Studies everolimus + vandetanib Sensitive : C4	everolimus + vandetanib Sensitive: C4 – Case Studies everolimus + vandetanib Sensitive : C4
ATM L804fs*4	Thyroid Gland Medullary Carcinoma	ATM L804fs*4	Thyroid Gland Medullary Carcinoma	everolimus + vandetanib Sensitive: C4 – Case Studies everolimus + vandetanib Sensitive : C4	everolimus + vandetanib Sensitive: C4 – Case Studies everolimus + vandetanib Sensitive : C4