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DRUG:

Cometriq (cabozantinib capsule)

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News alerts, weekly reports and conference planners

Company:

Exelixis, Ipsen, Royalty, Takeda

Drug class:

Multi-tyrosine kinase inhibitor

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No biomarker	Thyroid Gland Medullary Carcinoma	No biomarker	Thyroid Gland Medullary Carcinoma	cabozantinib capsule Sensitive: A1 - Approval cabozantinib capsule Sensitive : A1	cabozantinib capsule Sensitive: A1 - Approval cabozantinib capsule Sensitive : A1
RET M918T	Thyroid Gland Medullary Carcinoma	RET M918T	Thyroid Gland Medullary Carcinoma	cabozantinib capsule Sensitive: A2 - Guideline cabozantinib capsule Sensitive : A2	cabozantinib capsule Sensitive: A2 - Guideline cabozantinib capsule Sensitive : A2
RAS mutation	Thyroid Gland Medullary Carcinoma	RAS mutation	Thyroid Gland Medullary Carcinoma	cabozantinib capsule Sensitive: A2 - Guideline cabozantinib capsule Sensitive : A2	cabozantinib capsule Sensitive: A2 - Guideline cabozantinib capsule Sensitive : A2
KRAS mutation	Thyroid Gland Medullary Carcinoma	KRAS mutation	Thyroid Gland Medullary Carcinoma	cabozantinib capsule Sensitive: B - Late Trials cabozantinib capsule Sensitive : B	cabozantinib capsule Sensitive: B - Late Trials cabozantinib capsule Sensitive : B
NRAS mutation	Thyroid Gland Medullary Carcinoma	NRAS mutation	Thyroid Gland Medullary Carcinoma	cabozantinib capsule Sensitive: B - Late Trials cabozantinib capsule Sensitive : B	cabozantinib capsule Sensitive: B - Late Trials cabozantinib capsule Sensitive : B
KRAS mutation	Thyroid Gland Medullary Carcinoma	KRAS mutation	Thyroid Gland Medullary Carcinoma	cabozantinib capsule Sensitive: B - Late Trials cabozantinib capsule Sensitive : B	cabozantinib capsule Sensitive: B - Late Trials cabozantinib capsule Sensitive : B
MET mutation	Renal Cell Carcinoma	MET mutation	Renal Cell Carcinoma	cabozantinib capsule Sensitive: C2 – Inclusion Criteria cabozantinib capsule Sensitive : C2	cabozantinib capsule Sensitive: C2 – Inclusion Criteria cabozantinib capsule Sensitive : C2
RET fusion	Non Small Cell Lung Cancer	RET fusion	Non Small Cell Lung Cancer	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3
GNAQ mutation	Uveal Melanoma	GNAQ mutation	Uveal Melanoma	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3
GNA11 mutation	Uveal Melanoma	GNA11 mutation	Uveal Melanoma	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3
KIF5B-RET fusion	Non Small Cell Lung Cancer	KIF5B-RET fusion	Non Small Cell Lung Cancer	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3
CTNNB1 mutation	Non Small Cell Lung Cancer	CTNNB1 mutation	Non Small Cell Lung Cancer	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3	cabozantinib capsule Sensitive: C3 – Early Trials cabozantinib capsule Sensitive : C3