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DRUG:

Turalio (pexidartinib)

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Company:

Daiichi Sankyo

Drug class:

Multi-tyrosine kinase inhibitor

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No biomarker	Tenosynovial Giant Cell Tumor	No biomarker	Tenosynovial Giant Cell Tumor	pexidartinib Sensitive: A1 - Approval pexidartinib Sensitive : A1	pexidartinib Sensitive: A1 - Approval pexidartinib Sensitive : A1
FLT3-ITD mutation	Acute Myelogenous Leukemia	FLT3-ITD mutation	Acute Myelogenous Leukemia	pexidartinib Sensitive: C2 – Inclusion Criteria pexidartinib Sensitive : C2	pexidartinib Sensitive: C2 – Inclusion Criteria pexidartinib Sensitive : C2
FLT3 D835Y	Acute Myelogenous Leukemia	FLT3 D835Y	Acute Myelogenous Leukemia	pexidartinib Sensitive: C4 – Case Studies pexidartinib Sensitive : C4	pexidartinib Sensitive: C4 – Case Studies pexidartinib Sensitive : C4
CCND3 T283A	Acute Myelogenous Leukemia	CCND3 T283A	Acute Myelogenous Leukemia	pexidartinib Resistant: C4 – Case Studies pexidartinib Resistant : C4	pexidartinib Resistant: C4 – Case Studies pexidartinib Resistant : C4
CCND3 Q276* + CCND3 S264R	Acute Myelogenous Leukemia	CCND3 Q276* + CCND3 S264R	Acute Myelogenous Leukemia	pexidartinib Resistant: C4 – Case Studies pexidartinib Resistant : C4	pexidartinib Resistant: C4 – Case Studies pexidartinib Resistant : C4
FLT3 F691L	Acute Myelogenous Leukemia	FLT3 F691L	Acute Myelogenous Leukemia	pexidartinib Sensitive: D – Preclinical pexidartinib Sensitive : D	pexidartinib Sensitive: D – Preclinical pexidartinib Sensitive : D